Resistance Training in Patients With Chronic Obstructive Lung Disease (COPD): Whole Body Vibration Versus Conventional Resistance Training

COPD Clinical Trial

— REWORK  

Official title:

Resistance Training in Patients With Chronic Obstructive Lung Disease (COPD): Whole Body Vibration Versus Conventional Resistance Training

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01135966
• Other study ID #: 2010/157
• Status: Completed
• Phase: Phase 3
• First received: June 2, 2010
• Last updated: December 9, 2011
• Start date: April 2010
• Est. completion date: November 2011

Study information

• Verified date: December 2011
• Source: University Hospital, Ghent
• Contact: n/a
• Is FDA regulated: No
• Health authority: Belgium: Ethics Committee
• Study type: Interventional

Clinical Trial Summary

Pulmonary rehabilitation has been emerged as a recommended standard of care for patients with chronic lung disease based on a growing body of scientific evidence. A set of evidence-based guidelines were published in American College of Chest Physicians (ACCP) and the American Association of Cardiovascular and Pulmonary Rehabilitation (AACVPR). Since then, the published literature in pulmonary rehabilitation has increased substantially, and other societies have published important statements about pulmonary rehabilitation (eg, the American Thoracic Society and the European Respiratory Society).

In patients with COPD, there is a strong scientific basis for implementing conventional resistance training (CRT) in addition to endurance training. Endurance training, such as walking, is a key component of pulmonary rehabilitation and improves in exercise tolerance and muscular endurance. However, this type of training may not reverse muscle weakness or atrophy. For that reason, strength training seems to be the optimum training modality to increase muscle mass and strength.

Recently, Whole-Body-Vibration (WBV) training has been promoted as an alternative for resistance training on multigym equipment. In WBV training, the subject stands on a platform that generates vertical sinusoidal vibration, during which static and dynamic exercises can be performed.

The present study is conducted to provide an answer on the following question: will a resistance training program, such as the whole body vibration, be even effective than a conventional resistance training program in patients with COPD.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 62
• Est. completion date: November 2011
• Est. primary completion date: July 2011
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 40 Years to 80 Years

Eligibility

Inclusion Criteria:

• Patients with COPD candidate for pulmonary rehabilitation

• Men and female between 40 and 80 years of age

• Written informed consent to participate

Exclusion Criteria:

• Severe cardiac, neurological and orthopedic co-morbidity interfering with exercise training.

• Pacemaker

• Hip, knee of shoulder prosthesis or recently introduced spirals, metal pens, bolts or plates

• Uncontrolled diabetes, epilepsy or migraine

• Osteoporotic or metastatic fractures, acute hernia, discopathy, spondylitis

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• COPD
• Lung Diseases
• Lung Diseases, Obstructive
• Pulmonary Disease, Chronic Obstructive

Intervention

Behavioral:
• Conventional resistance training program
Conventional resistance training program is followed.
• Whole body vibration resistance training program
WBV training on FITVIBE

Locations

Country	Name	City	State
Belgium	University Hospital Ghent	Ghent

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Ghent

Country where clinical trial is conducted

Belgium, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	estimation of the change of 6 MWD before and after 12 weeks resistance training program (CRT versus WBV training)	estimation of the change of 6 MWD (submaximal walking test)after a 12 week conventional resistance training program or after a 12 week whole body vibration training program	before and after 12 weeks	Yes
Secondary	changes in muscle strength (quadriceps force)after CRT or after WBV training in patients with COPD	measured by modified Microfet before and after 12 weeks of training.	before and after 12 weeks	No
Secondary	changes in body composition after CRT or after WBV training in patients with COPD	measured by bioelectrical impedance analysis: Fat Free Mass (FFM)before and after 12 weeks of training.	before and after 12 weeks	No
Secondary	changes in maximal exercise capacity after CRT or after WBV training in patients with COPD	measured by cyclo-ergospirometry before and after 12 weeks of training	before and after 12 weeks	No
Secondary	changes in muscle force after CRT or after WBV training in patients with COPD	measured by handgrip force, maximal inspiratory pressure (PImax) and maximal expiratory pressure (PEmax)before and after 12 weeks of training	before and after 12 weeks	No
Secondary	changes in Quality of life after CRT or after WBV training in patients with COPD	measured by CRDQ (Chronic Respiratory Disease Questionnaire)before and after 12 weeks of training	beforer and after 12 weeks	No
Secondary	changes in Dyspnea scores after CRT or after WBV training in patients with COPD	measured by Chronic Respiratory Disease Questionnaire domain dyspnea (CRDQd) and by the BORG scale before and after 12 weeks of training.	before and after 12 weeks	No
Secondary	changes in 6MWD and the endurance test on the bicycle after CRT or after WBV training in patients with COPD	measured by endurance test on the bicycle (75% Max. Workload)before and after 12 weeks of training. This test will also be repeated after 6 weeks of training.	before and after 12 weeks	No

External Links

•   website of University Hospital Ghent