COPD Clinical Trial
Official title:
The Clinical Impact of Anemia of Chronic Disease on Chronic Obstructive Pulmonary Disease Patients
Hypothesis:
The first part of the study is a survey on the prevalence of anemia of chronic disease (ACD)
among COPD patients. The 2nd and 3rd part will test 2 null hypotheses (Ho): 1.serum
inflammatory markers and plasma erythropoietin do not differ between COPD patients with and
without ACD and 2. exercise capacity does not differ between COPD patients with and without
ACD.
Rationale-Aim:
ACD is an immune driven disorder, developing in subjects suffering from chronic inflammatory
diseases. COPD is a disorder very likely to be associated to ACD due to its systemic
inflammatory dimension. Currently, data on the prevalence of ACD and on the level of
inflammatory markers which are implicated in the pathogenesis of ACD in COPD subjects are
limited and controversial. Furthermore, there is no data on the effect of ACD on exercise
capacity of COPD subjects.
Based to the aforementioned, this study has three goals:
1. to determine the prevalence and the epidemiologic characteristics of ACD in a
population of clinical stable COPD patients
2. to investigate whether the levels of serum inflammatory markers and of plasma
erythropoietin differ between COPD patients with ACD and without ACD
3. to determine potential differences regarding the aerobic exercise capacity between
these two groups, using the cardiopulmonary exercise testing (CPET).
n/a
Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Screening
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