Chronic Obstructive Pulmonary Disease Clinical Trial
Official title:
How Smoking Causes COPD: Examination of Immune System Changes
A breathing condition known as "chronic obstructive pulmonary disease" (COPD) caused by cigarette smoking is a major health problem. The way by which smoking leads to lung disease is uncertain. Recent research done in animals provides a description of specific changes (that is a reduction) in these immune cell types as a result of cigarette smoke exposure. The study you have been asked to participate in is a pilot study to see if similar changes occur in humans who smoke. The purpose of this study is to evaluate this new method of testing blood in 3 groups of 10 people: normal non-smoking subjects, subjects who smoke with no history of lung disease and subjects who smoke and have smoking related COPD.
Status | Recruiting |
Enrollment | 100 |
Est. completion date | April 2012 |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 40 Years and older |
Eligibility |
Inclusion Criteria: - Age > 40 years - Healthy Subjects - Non smokers - FEV1/FVC > 70% predicted - Current Smokers - > 10 pack year smoking history - FEV1/FVC > 70% predicted - Current Smokers with COPD - > 10 pack year smoking history - FEV1/FVC < 70% predicted - Able to give informed consent Exclusion Criteria: - Healthy Subjects - Reside with smokers - History of lung disease - Current Smokers - History of lung disease |
Observational Model: Cohort, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Canada | St Joseph's Healthcare | Hamilton | Ontario |
Lead Sponsor | Collaborator |
---|---|
St. Joseph's Healthcare Hamilton |
Canada,
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