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Airway Clearance for Prevention of Chronic Obstructive Pulmonary Disease (COPD) Exacerbation

COPD Clinical Trial

Official title:
A Randomized, Sham-controlled, Double-blinded Pilot Study to Assess the Effects of High Frequency Chest Wall Oscillation (HFCWO) Therapy in Patients With Chronic Bronchitis

Clinical Trial Summary

The purpose of this study is to show that one form of mechanical airway clearance techniques, High Frequency Chest Wall Oscillation (HFCWO)using a pneumatic vest, will diminish exacerbations of COPD which will improve respiratory health status.

Clinical Trial Description

Approximately 60 to 70% of people with COPD have chronic cough and phlegm, the cardinal symptoms of chronic bronchitis or chronic mucus hypersecretion (CMH). Once thought to be a relatively benign condition, recent evidence shows that CMH in patients with established COPD is associated with greater decline in lung function, more frequent respiratory infections, more frequent exacerbations and increased mortality.Using mechanical airway clearance techniques (The Vest) will diminish exacerbations of COPD which will improve respiratory health status.

Comparison: Patients randomly assigned to the vest will have fewer exacerbations of COPD,better quality of life and less health care use compared to patients assigned to a sham vest. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00181207
Study type Interventional
Source Johns Hopkins University
Contact
Status Completed
Phase Phase 4
Start date May 2004
Completion date December 2007
View Details
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