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NCT00159367 Clinical Trial

The Use of Repetitive Magnetic Stimulation for Strength Training of the Quadriceps Muscle

Chronic Obstructive Pulmonary Disease Clinical Trial

Official title:
The Use of Repetitive Magnetic Stimulation for Strength Training of the Quadriceps Muscle in Patients With Chronic Obstructive Pulmonary Disease

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00159367
Other study ID # RR1
Secondary ID EU QLRT-2001-228
Status Completed
Phase N/A
First received
Last updated
Start date January 2005
Est. completion date February 2006

Study information
Verified date September 2023
Source Imperial College London
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

We intend to use repetitive magnetic stimulation to the quadriceps muscle to try to improve strength and improve the metabolic function of the muscle.

Description:

Quadriceps strength is reduced in COPD. Increasing quadriceps strength is one of the goals of pulmonary rehabilitation yet some patients with severe COPD are unable to exercise with sufficient intensity, due to breathlessness, to achieve a true training benefit. Transcutaneous electrical stimulation of the femoral nerve has been shown to improve quadriceps muscle strength, muscle mass, and performance in patients with severe COPD. Magnetic stimulation may be preferred because it offers the opportunity to train the whole muscle and because it is painless. In this pilot study we are investigating whether repetitive magnetic stimulation camn increase the strength of the quadriceps muscle and whether it confers any change in structure or metabolism of the muscle itself.

Recruitment information / eligibility
Status Completed
Enrollment 20
Est. completion date February 2006
Est. primary completion date February 2006
Accepts healthy volunteers No
Gender All
Age group 40 Years to 85 Years
Eligibility Inclusion Criteria: Chronic Obstructive Pulmonary Disease Exclusion Criteria: Aspirin therapy Cardiac Pacemaker -

Study Design

Related Conditions & MeSH terms

Intervention

Device:
• Repetitive magnetic stimulation to the quadriceps

Locations
Country Name City State
United Kingdom Royal Brompton Hospital London

Sponsors (2)
Lead Sponsor Collaborator
Imperial College London Magstim Company, Whitland, Wales

Country where clinical trial is conducted

United Kingdom, 

Outcome
Type Measure Description Time frame Safety issue
Primary Quadriceps Twitch force
Secondary Quadriceps maximal voluntary contraction, Oxidative enzyme profile, fibre type distribution and capillarity of the muscle, quality of life questionnaires
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