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The Role of Congenital Mucosal Immune System in the Airways of Patients With Chronic Obstructive Pulmonary Disease

COPD Exacerbation Clinical Trial

Official title:
The Role of Congenital Mucosal Immune System in the Airways of Patients With COPD

Clinical Trial Summary

The purpose of the study is to explore the role of congenital mucosal immune system in the airways of patients with COPD including the impact of ILCs (Innate lymphoid cells) on metabolism of epithelial cells.During the research the following methods will be applied: measurement of Volatile Organic Compounds (VOCS), airway epithelial cytology and culture.

Clinical Trial Description

ILCs profiles, epithelium metabolism measured by VOCS and microbiome profiling (specific 16S rRNA-16S ribosomal RNA gene-targeted qPCR) will by determined in the airways of patients with COPD after the exacerbation. Microbiome profiling will be based on next generation sequencing (NGS) of the 16S rRNA encoding region. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04061122
Study type Observational
Source Medical Universtity of Lodz
Contact Pawel Majak
Phone 600621878
Email pmajak@o2.pl
Status Recruiting
Phase
Start date July 4, 2018
Completion date June 30, 2020
View Details
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