Cough Frequency in Chronic Obstructive Pulmonary Disease

Status Completed

Clinical Trial Summary

Acute exacerbations of COPD remain a common cause of morbidity and are associated with a sustained increase in the normal respiratory symptoms of dyspnoea, cough, and sputum volume and purulence. It has previously been shown that a change in cough symptoms occurs in 51.7% of exacerbations in COPD. We wish to record cough during a COPD exacerbation to determine whether this can be a objective marker of exacerbation duration and severity.

Clinical Trial Description

Acute exacerbations of COPD remain a common cause of morbidity and are associated with a sustained increase in the respiratory symptoms of dyspnoea, cough, sputum volume and sputum purulence. Cough is one of the most commonly reported and key symptoms in COPD patients. Cough can also be a useful factor in finding patients at risk of progressive airflow obstruction and cough along with the breathlessness is the major cause of distress in patients with chronic obstructive airways disease (COPD). There is limited literature looking into cough and COPD especially objective assessments.

in clinical practice and in most clinical trials scoring systems ie quality of life questionnaires or visual analogue scores, have been used to measure COPD exacerbation severity, although these may give an indication of the perceived severity of the symptom, they are inherently subjective and may be influenced by other factors. Shortfalls have prompted the development of cough recorders as an objective measure of this symptom. With this in mind we propose recruit 30 subjects with non-infective exacerbations of COPD and monitor their cough frequency as an inpatient in acute exacerbation and for 45 days post hospital discharge in order to elucidate the natural history of cough during and after an exacerbation. ;

Study Design

Related Conditions & MeSH terms

COPD Exacerbation
Pulmonary Disease, Chronic Obstructive

Clinical Trial Details

NCT number	NCT01405222
Study type	Observational
Source	Hull and East Yorkshire Hospitals NHS Trust
Contact
Status	Completed
Phase
Start date	January 2012
Completion date	July 2013

View Details

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT06000696` - Healthy at Home Pilot
Recruiting	`NCT03250000` - Changes in Microcirculation and Functional Status During Exacerbation of COPD	N/A
Recruiting	`NCT04142827` - The Effect of Long Term Therapy With High Flow Humidification Compared to Usual Care in Patients With Bronchiectasis (BX)	N/A
Recruiting	`NCT05865184` - Evaluation of Home-based Sensor System to Detect Health Decompensation in Elderly Patients With History of CHF or COPD
Completed	`NCT01892566` - Using Mobile Health to Respond Early to Acute Exacerbations of COPD in HIV	N/A
Completed	`NCT04119856` - Outgoing Lung Team - a Cross-sectorial Intervention in Patients With COPD	N/A
Recruiting	`NCT06118632` - Physiological and Environmental Data in a Remote Setting to Predict Exacerbation Events in Patients With Chronic Obstructive Pulmonary Disease
Recruiting	`NCT04860375` - Multidisciplinary Management of Severe COPD	N/A
Completed	`NCT04170361` - The Effect of Incentive Spirometry Added to Routine Physiotherapy Program on Hemodynamic Responses and Hospital Stay in Patients With COPD Exacerbation	N/A
Not yet recruiting	`NCT03696563` - FreeO2 PreHospital - Automated Oxygen Titration vs Manual Titration According to the BLS-PCS	N/A
Not yet recruiting	`NCT03296215` - Pattern of Admitted Cases in Respiratory Intensive Care Unit at Assiut University Hospitals	N/A
Completed	`NCT02912689` - NIV - NAVA vs NIV - PS for COPD Exacerbation	N/A
Completed	`NCT03003702` - Domiciliary Monitoring to Predict Exacerbations of COPD	N/A
Recruiting	`NCT02264483` - Low-dose CT for Diagnosis of Pneumonia in COPD Exacerbations and Comparison of the Inflammatory Profile.	N/A
Completed	`NCT01443845` - Roflumilast in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Fixed Dose Combinations of Long-acting β2-agonist (LABA) and Inhaled Corticosteroid (ICS)	Phase 4
Recruiting	`NCT02065921` - Swiss Chronic Obstructive Pulmonary Disease (COPD) Management Cohort
Completed	`NCT04880486` - Weight Training With VR in Out-Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease	N/A
Recruiting	`NCT03286127` - Palliative Outcome Evaluation Muenster I
Recruiting	`NCT04638920` - Molecular Breath Print of COPD Patients With Exacerbations Despite Triple Inhalational Therapy
Not yet recruiting	`NCT05897125` - Telehealth Education Leveraging Electronic Transitions Of Care for COPD Patients	N/A