Exercise and Neural Response to Food Cues in Children

Control Session (CON) Clinical Trial

Official title:

Effect of Exercise on the Neural Response to Food Cues and Energy Intake in Lean and Obese Adolescents

Clinical Trial Details — Status: Withdrawn

Administrative data

• NCT number: NCT02100878
• Other study ID #: AU1107
• Status: Withdrawn
• Phase: N/A
• First received: March 27, 2014
• Last updated: April 1, 2014
• Start date: March 2014
• Est. completion date: March 2015

Study information

• Verified date: April 2014
• Source: Université Blaise Pascal, Clermont-Ferrand
• Contact: n/a
• Is FDA regulated: No
• Health authority: French: National Agency for medication and health products Security (ANSM)
• Study type: Observational

Clinical Trial Summary

Physical exercise has been shown to significantly reduce subsequent energy intake in obese adolescents but not in lean, without altering their appetite feelings. Although previous studies have pointed out the role of gastric peptides in this post exercise nutritional response, some recent work question the role of the neural system in the post exercise drive to eat. This study tends to explore whether or not an acute bout of exercise can affect the neural response to food cues in adolescents, obese or lean.

Description:

After a medical inclusion, the adolescents will have to realise a DXA to assess their body composition and a submaximal exercise to evaluate their aerobic capacities.

They will have then to enter the laboratory on 2 different occasions in a randomized order from 8am to 330pm: At 8am they will receive a calibrated breakfast. then, at 1045; they will have to complete one of the experimental condition: 1) a cycling exercise or 2) remaining sitting fpr one hour. after the one hour sitting station or the exercise bout, they will be asked to complete a computer task while and electroencephalogram will be recorded. This computer task consists in visual recognition of rare pictures compared to frequent ones (oddball method). at 1215 they will be offered ad libitum meals. At regular intervals through the day, their appetite feelings will be assessed using Visual analogue scales.

Ad libitum energy consumption will be assessed by investigators and recorded for each participants.

Recruitment information / eligibility

• Status: Withdrawn
• Enrollment: 0
• Est. completion date: March 2015
• Est. primary completion date: March 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 12 Years to 15 Years

Eligibility

Inclusion Criteria:

• male

• 12-15 years old

• BMI defining obesity (Cole et al., 2000)

• Not being under diet restriction

• Information and consent forms have to be signed by the adolescent and his legal representative

• being registered to the national social security system

Exclusion Criteria:

• Being under medication

• contraindication to exercise

• smokers

• dieting

Study Design

Observational Model: Case-Crossover, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• Control Session (CON)
• Exercise Condition (EX)

Locations

Country	Name	City	State
France	Laboratory AME2P	Aubiere

Sponsors (1)

Lead Sponsor	Collaborator
Université Blaise Pascal, Clermont-Ferrand

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Neural response to food cues	The electroencephalogram signals amplitude in response to visual food cues will be the primary outcome, after the exercise (during the exercise condition) and after the sitting position (during the control session)	up to 2 months