Injectable Contraception Cohort Study in Punjab, Pakistan

Status Active, not recruiting

Clinical Trial Summary

The aim of this study is to assess the value proposition of expanding contraceptive options available to women in Punjab, Pakistan to include subcutaneous depot medroxyprogesterone acetate (DMPA-SC). Specific objectives are: 1. To compare 12-month continuation rates for DMPA-SC and intramuscular DMPA (DMPA-IM) among married women 18- 49 years of age in two districts of Punjab, Pakistan 2. To understand how characteristics and experiences of DMPA-SC and DMPA-IM users differ. 3. To assess how well women opting for self-injection of DMPA-SC adhere to standards for commodity storage, injection timing, injection technique, and waste disposal

Clinical Trial Description

Depot medroxyprogesterone acetate (DMPA) is a highly-effective, injectable contraceptive method that requires injections every 11 to 17 weeks. It is available in both intramuscular (IM) and subcutaneous (SC) formulations, which are therapeutically equivalent and have similar safety profiles. DMPA-IM has been included in the method mix for most countries for many years. DMPA-SC is a newer formulation being added to the method mix in select settings. Studies demonstrate that self-administration of subcutaneous DMPA (DMPA-SC) outside clinical settings is safe, effective, feasible, acceptable, and can improve continuation, and a recommendation in favor of self-injected DMPA-SC is included in WHO guidelines on self-care interventions for health and well-being. The Bill and Melinda Gates Foundation is funding implementation research in multiple countries to understand how self-injection of DMPA-SC can best be introduced to specific markets to expand the contraceptive options available to women and girls, health system characteristics, the demand for self-injection when DMPA-SC is offered alongside a range of other methods, and women's and girl's ability to start and continue use. Jhpiego has received funding to conduct one of these 'market tests' in Punjab, Pakistan. The aim of this study is to assess the value proposition of expanding contraceptive options available to women in Punjab, Pakistan to include subcutaneous depot medroxyprogesterone acetate (DMPA-SC). Specific objectives are: 1. To compare 12-month continuation rates for DMPA-SC and intramuscular DMPA (DMPA-IM) among married women 18- 49 years of age in two districts of Punjab, Pakistan 2. To understand how characteristics and experiences of DMPA-SC and DMPA-IM users differ. 3. To assess how well women opting for self-injection of DMPA-SC adhere to standards for commodity storage, injection timing, injection technique, and waste disposal ;

Study Design

Related Conditions & MeSH terms

Contraceptive Usage

Clinical Trial Details

NCT number	NCT05774626
Study type	Observational
Source	Jhpiego
Contact
Status	Active, not recruiting
Phase
Start date	January 18, 2024
Completion date	June 30, 2025

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03279120` - Safety, PK, and PD Study of IVRs Releasing TFV and LNG	Phase 1
Withdrawn	`NCT03725358` - A Cluster-RCT to Increase the Uptake of LARCs Among Adolescent Females and Young Women in Cameroon.	N/A
Completed	`NCT01170390` - Oral Contraceptives and Body Mass Index	Phase 4
Recruiting	`NCT05932537` - Ablation of Subcutaneous Contraceptive Implants in the Operating Room
Withdrawn	`NCT04882137` - Barriers to Referring Adolescent Women for Etonogestrel Implant.	N/A
Completed	`NCT02613039` - Oral Contraceptive Therapy and Sexuality	Phase 4
Completed	`NCT01425060` - Improving Effective Contraceptive Use Among Opioid-maintained Women	Phase 1
Completed	`NCT03626597` - Community-based Provision of Urine Pregnancy Tests as Linkage to Reproductive Health Services	N/A
Recruiting	`NCT04558229` - RCT Evaluating Standardized Counseling on Early Discontinuation for Irregular Bleeding in Nexplanon Users	Phase 4
Recruiting	`NCT05644886` - Pilot Study on Engaging Family Physicians in Family Planning in Pakistan	N/A
Completed	`NCT04043130` - The Evaluation of Pulse: A Mobile Health App and Teen Pregnancy Prevention Program	N/A
Completed	`NCT03571932` - Assessment of Family Planning and Immunization Service Integration in Liberia
Completed	`NCT03253783` - The Evaluation of Pulse: A Mobile Health App and Teen Pregnancy Prevention Program	N/A
Completed	`NCT03336346` - Effect of Dolutegravir on Etonogestrel Levels in HIV-infected Women in Botswana
Active, not recruiting	`NCT03984695` - Sexual Health Empowerment for Women's Health	N/A
Completed	`NCT02411357` - Improving Effective Contraceptive Use Among Opioid-maintained Women: Stage II	N/A
Completed	`NCT05806463` - Efficacy of Mother's Time in Ethiopia	N/A
Recruiting	`NCT05328648` - Randomized Controlled Trial to Address Unintended Pregnancy Rates in Low Resource Settings	N/A
Active, not recruiting	`NCT05061472` - A 6-month Observational Study on Combined Oral Contraceptives and Body Weight in Pre-Menopausal Women With Overweight or Obesity
Not yet recruiting	`NCT05988983` - The Over The Counter Pill National Study