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Constriction, Pathologic clinical trials

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NCT ID: NCT03997994 Active, not recruiting - Biliary Stricture Clinical Trials

DIGEST I Drug Coated Balloon for Biliary Stricture

DIGEST
Start date: May 12, 2019
Phase: N/A
Study type: Interventional

DIGEST I Pilot study is a feasibility study for evaluating the safety and efficacy of DCBs.

NCT ID: NCT03931161 Active, not recruiting - Clinical trials for Carotid Artery Stenosis

Effect of Evolocumab on Carotid Plaque Composition in Asymptomatic Carotid Artery Stenosis (EVOCAR-1)

EVOCAR-1
Start date: September 4, 2019
Phase: Phase 4
Study type: Interventional

This is a phase IV, randomised, placebo-controlled, double-blind, parallel group study to determine the effect of Evolocumab treatment on carotid plaque morphology and composition in asymptomatic patients with >50% carotid artery stenosis.

NCT ID: NCT03886324 Active, not recruiting - Clinical trials for Intestinal Stricture

POISE I Pilot Study

POISE
Start date: February 25, 2019
Phase: N/A
Study type: Interventional

POISE I study is a feasibility study for evaluating the safety and efficacy of DCB.

NCT ID: NCT03885310 Active, not recruiting - Clinical trials for Esophageal Stricture

INGEST I Pilot Study

INGEST
Start date: February 24, 2019
Phase: N/A
Study type: Interventional

INGEST I Pilot study is a feasibility study for evaluating the safety and efficacy of DCBs.

NCT ID: NCT03879447 Active, not recruiting - Low Back Pain Clinical Trials

Effectiveness and Safety of Korean Medicine for Low Back Pain or Sciatica Due to Lumbar Stenosis/Spondylolisthesis

Start date: June 24, 2019
Phase:
Study type: Observational

A prospective observational study investigating the effectiveness and safety of integrative Korean medicine treatment in lumbar stenosis or spondylolisthesis patients with low back pain or sciatica at 3 locations of Jaseng Hospital of Korean Medicine as assessed through of pain, functional disability, walking ability, and quality of life patient-reported outcomes

NCT ID: NCT03863132 Active, not recruiting - Clinical trials for Aortic Valve Stenosis

accuRate Evaluation of Benefit With Optimal Medical Treatment With or Without Transcatheter Valve Repair of PARADOXical Low Flow Low Gradient Aortic Stenosis

REBOOT-PARADOX
Start date: July 3, 2019
Phase: N/A
Study type: Interventional

Aim of this study is to evaluate whether microsurgical repair or replacement of the aortic valve is a treatment option for a subgroup of patients suffering from aortic Stenosis.

NCT ID: NCT03754972 Active, not recruiting - Clinical trials for Lumbar Spinal Stenosis

Sagittal Plane Shear Index for Planning Lumbar Stenosis Surgery

SPSI
Start date: February 20, 2019
Phase: N/A
Study type: Interventional

The objective of the clinical investigation is to assess the proportion of lumbar spinal stenosis surgical treatment plans that change when an objective measurement of spinal stability is included and applied following a simple treatment algorithm. The objective spinal stability metric is calculated from flexion-extension radiographs using previously validated methods.

NCT ID: NCT03752866 Active, not recruiting - Clinical trials for Severe Aortic Stenosis

The CONFIDENCE Registry

Start date: October 25, 2018
Phase: N/A
Study type: Interventional

The purpose of this clinical investigation is to characterize the procedural safety and device performance of transfemoral implantation of the Porticoâ„¢ Transcatheter Aortic Heart Valve in patients with symptomatic degenerative aortic stenosis.

NCT ID: NCT03703635 Active, not recruiting - Clinical trials for Intracranial Artery Stenosis

Balloon Angioplasty for Symptomatic Intracranial Artery Stenosis

BASIS
Start date: October 17, 2018
Phase: N/A
Study type: Interventional

Intracranial atherosclerotic disease (ICAD) is the most common cause of ischemical cerebrovascular events. The risk of stroke recurrence or death of ICAD patients remains very high. Even with aggressive medical management including dual antiplatelet therapy and strict management of risk factors, 12.2 percent of patients with 70-99 percent stenosis of intracranial artery had stroke or death during 1 year follow-up. In the real world, the 30-day risk of recurrent stroke of patients with aggressive medical management was as high as 20.2 percent. Balloon angioplasty and stent for intracranial artery have become important alternative treatments to prevent recurrent stroke for patients with severe intracranial atherosclerotic stenosis. Nevertheless, the SAMMPRIS trial has suggested intracranial stenting has higher stroke and death rate than aggressive medication with high peri-procedure complication rate. Previous nonrandomized studies have showed that stroke and death rate of angioplasty for ICAD patients with severe stenosis of intracranial artery is lower than that of aggressive medication. The primary purpose of this trial is to compare intracranial angioplasty plus aggressive medical management with aggressive medical management alone for the treatment of patients with 70-99 percent intracranial artery stenosis because of ICAD and to clarify the efficacy and safety of intracranial angioplasty through a multicenter, prospective, randomized, open-label, blinded end-point trial.

NCT ID: NCT03610737 Active, not recruiting - Clinical trials for Spinal Stenosis, Lumbar Region, With Neurogenic Claudication

The MOTION Study - Treatment of LSS With the MILD Procedure

Start date: August 2, 2018
Phase: N/A
Study type: Interventional

Prospective, multicenter, randomized controlled clinical study examining functional improvement in lumbar spinal stenosis (LSS) patients with neurogenic claudication who are treated with the MILD procedure plus conventional medical management (CMM) compared to those treated with CMM alone, as the control. Subjects in the control group are able to crossover and receive MILD after completion of 12-month follow-up. The study will provide objective functional improvement data for patients treated with the mild Procedure as first-line therapy in a real-world setting.