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Conjunctivitis clinical trials

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NCT ID: NCT06329687 Terminated - Dry Eye Clinical Trials

A Study Evaluating the Safety of the Nasal Pump

Start date: February 21, 2024
Phase: Phase 4
Study type: Interventional

The objective of this study is to determine the safety of the Tyrvaya nasal pump.

NCT ID: NCT05263505 Terminated - Clinical trials for Mucous Membrane Pemphigoid

Baricitinib for the Treatment of Ocular Mucous Membrane Pemphigoid

Start date: February 21, 2022
Phase: Phase 2
Study type: Interventional

Ocular mucous membrane pemphigoid (MMP) is an autoimmune, scarring conjunctivitis that can lead to vision loss and permanent disability. It is a rare disorder with an estimated incidence of 1 in 60,000. There are currently no FDA-approved medications for the treatment of mucous membrane pemphigoid, highlighting a clear unmet need. At present, moderate to severe disease requires off-label use of potent immunosuppressive agents, such as oral anti-proliferatives (methotrexate, azathioprine, and mycophenolate), rituximab (RTX) or cyclophosphamide (CyC). Recently, Janus kinase (JAK) inhibition with baricitinib or tofacitinib been reported to be successful in one case of ocular MMP. This is a randomized, single-masked, two-arm study of baricitinib vs anti-proliferatives for ocular MMP.

NCT ID: NCT04874714 Terminated - Clinical trials for Perennial Allergic Rhinitis

Efficacy and Safety Evaluation for the Treatment of Asthma and Allergic Rhinitis/Rhinoconjunctivitis

Start date: April 30, 2021
Phase: Phase 3
Study type: Interventional

Prospective, randomized, placebo-controlled, multicenter of 3 active treatment groups, compared to 1 placebo group, for the determination of the efficacy and safety of subcutaneous immunotherapy in patients with mild to moderate asthma and allergic rhinitis/rhinoconjunctivitis (intermittent or persistent) due to hypersensitivity to house dust mites (Dermatophagoides pteronyssinus and / or D. farinae) and grass pollen

NCT ID: NCT04176185 Terminated - Clinical trials for Allergic Rhinoconjunctivitis

A Research Study in Chinese People With Allergy to House Dust Mites, Using an Environmental Exposure Chamber

QUEST
Start date: November 4, 2019
Phase: Phase 3
Study type: Interventional

This trial evaluates the efficacy and safety of HDM SLIT-tablet in treatment of HDM AR. The efficacy is evaluated using an environmental exposure chamber (EEC). Subjects will be randomised to receive treatment with HDM SLIT-tablet and placebo 1:1.

NCT ID: NCT03861728 Terminated - Clinical trials for Viral Conjunctivitis

Viral Conjunctivitis Treatment Study

Start date: November 14, 2018
Phase: N/A
Study type: Interventional

The objective of this study is to determine the efficacy Avenova® (0.01% hypochlorous acid) in the treatment of viral conjunctivitis. The investigators hypothesize that patients treated with Avenova® will have a quicker resolution of their ocular signs and symptoms of Viral Conjunctivitis compared with artificial tears.

NCT ID: NCT03696342 Terminated - Clinical trials for Conjunctivitis, Bacterial

Efficacy of the Ophthalmic Pazufloxacin 0.6% for Bacterial Conjunctivitis, Compared to Gatifloxacin 0.3%.

PRO-157
Start date: October 1, 2018
Phase: Phase 3
Study type: Interventional

Phase III clinical study of non-inferiority, multicenter, double-blind, with comparative group, of parallel groups and randomized. about a ophthalmic topical antibiotic for the treatment of bacterial conjunctivitis. Goal:To compare the efficacy of the ophthalmic solution of pazufloxacin 0.6%, against the ophthalmic solution of gatifloxacin 0.3%, in the treatment of acute bacterial conjunctivitis. Hypothesis:the ophthalmic solution PRO-157 is not inferior in the treatment of bacterial conjunctivitis, compared to the ophthalmic solution of gatifloxacin 0.3%, by means of the clinical remission of the disease. Number of patients: 160 patients, each one will provide an eye for efficacy analysis, divided into 2 groups (80 eyes per group).

NCT ID: NCT03627689 Terminated - Asthma Clinical Trials

Molekule for Allergic Rhinitis/Asthma

Start date: July 13, 2018
Phase: N/A
Study type: Interventional

Exposure to airborne allergens and pollutants is linked to symptom severity of allergies, asthma and other respiratory problems. In this study an air purifier using photo-electrochemical oxidation technology (PECO) will be used in the home environment of study participants. The investigator will assess the reduction of symptoms from allergic rhinitis/conjunctivitis and asthma.

NCT ID: NCT03038971 Terminated - Allergic Rhinitis Clinical Trials

Study Evaluating Safety of Ragweed Mix Given by Intralymphatic Node Injections

Start date: March 30, 2017
Phase: Phase 1
Study type: Interventional

A safety study conducted on subjects ≥16 years old evaluating the safety of 4 intralymphatic injections of 2 different dose levels of the investigational short and tall ragweed product. Biomarkers will be assessed at baseline and at multiple time points post-treatment.

NCT ID: NCT02998554 Terminated - Clinical trials for Adenoviral Conjunctivitis

Treatment of Adenoviral Conjunctivitis With SHP640 Compared to Placebo

Start date: March 28, 2017
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine if an investigational treatment is effective compared with placebo in the treatment of adults and children with adenoviral conjunctivitis.

NCT ID: NCT02998541 Terminated - Clinical trials for Adenoviral Conjunctivitis

Treatment of Adenoviral Conjunctivitis With SHP640 Compared to Povidone-iodine (PVP-I) and Placebo

Start date: March 27, 2017
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine if an investigational treatment is effective compared with placebo and PVP-Iodine in the treatment of adults and children with adenoviral conjunctivitis.