Congenital Urine Flow Impairment Clinical Trial
Official title:
Change of Urinary Metabolic Profile Secondary to a Congenital Urine Flow Impairment (UFI) by Nuclear Magnetic Resonance (NMR) and Metabolomics Analysis
For the new-born, diagnosis and prognosis of congenital urine flow impairment (UFI) are
difficult to confirm only with morphological examination (ultrasonography, intravenous
pyelography) and functional examination (dynamic renal scan MAG3). Only the test of time
allows the post confirmation of a significant UFI requiring a surgery. This meant that the
actual therapeutic indications are imperfect by the absence of an "absolute" endpoint for
UFI.
The objective of the study is to characterize the urinary metabolomics profile of new born
with renal pelvis and/or ureters tract dilatation (suspicion of pelvi-ureteric junction
anomalies, primary megaureter and vesico-ureteric reflux), detected by prenatal
ultrasonography, by Nuclear Magnetic Resonance (NMR) and metabolomics analysis. This
characterization will allow the identification of statistically significant metabolomics
markers for the diagnosis and prognosis of a favourable evolution of the anomaly. The
evolution with time of these metabolomics profiles will also considered.
n/a
Observational Model: Cohort, Time Perspective: Prospective