Congenital Hypothyroidism Clinical Trial
Official title:
Final Height in Patients With Congenital Hypothyroidism Diagnosed by Neonatal Screening
The aim of this study is to evaluate longitudinal growth and final height in patients with Congenital Hypothyroidism detected by neonatal screening and factors affecting it.
Status | Not yet recruiting |
Enrollment | 60 |
Est. completion date | April 1, 2022 |
Est. primary completion date | March 1, 2022 |
Accepts healthy volunteers | No |
Gender | All |
Age group | N/A and older |
Eligibility | Inclusion Criteria: - Patients having a documented history of CH diagnosed by Egyptian neonatal screening program. - Patients receiving L-thyroxine (L-T4) since the diagnosis is established. Exclusion Criteria: - Patients who are non-compliant on L-thyroxine (L-T4) and failed to follow up at the clinic on regular basis. - Patients who were missed from diagnosis by neonatal screening. - Patients with associated hormonal disorders affecting same parameters concerned in the study. |
Country | Name | City | State |
---|---|---|---|
Egypt | Ain Shams University | Cairo | Abbasiya |
Lead Sponsor | Collaborator |
---|---|
Ain Shams University |
Egypt,
Bain P, Toublanc JE. Adult height in congenital hypothyroidism: prognostic factors and the importance of compliance with treatment. Horm Res. 2002;58(3):136-42. — View Citation
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Bauer AJ, Wassner AJ. Thyroid hormone therapy in congenital hypothyroidism and pediatric hypothyroidism. Endocrine. 2019 Oct;66(1):51-62. doi: 10.1007/s12020-019-02024-6. Epub 2019 Jul 26. Review. — View Citation
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Salerno M, Micillo M, Di Maio S, Capalbo D, Ferri P, Lettiero T, Tenore A. Longitudinal growth, sexual maturation and final height in patients with congenital hypothyroidism detected by neonatal screening. Eur J Endocrinol. 2001 Oct;145(4):377-83. — View Citation
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* Note: There are 12 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Assessment of change of Final Height in patients with Congenital Hypothyroidism diagnosed by neonatal screening | The investigators assess the effect of early diagnosis and early levothyroxine start on the change in longitudinal growth in patients with Congenital Hypothyroidism. | Since the diagnosis is established by neonatal screening during first week of life height will be assessed every 6 months with follow up throughout the study period until the study subject reaches an average of 18 years of age( final height reached). |
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