Daclizumab Experience in Pediatric Heart Transplant

Status Terminated

Clinical Trial Summary

The purpose of this study is to examine the outcomes of those who have received Daclizumab as part of their immuno-suppression protocol following heart transplantation. Literature suggests that the time to first rejection episode can be avoided or delayed by using induction therapy.

Clinical Trial Description

In August 2005 the heart transplant team at Children's Healthcare of Atlanta began a protocol of Daclizumab 1mg/kg IV every two weeks for 5 doses; 1st dose to be received in the operating room following discontinuation of cardiopulmonary bypass.

Since one year has passed following initiation of this practice, it is necessary to review this immuno-suppression strategy and determine if, in fact, there was clinical benefit of reducing rejection without increasing the vulnerabilities of the immuno-compromised host.

We wish to review all heart transplant recipient records between August 1, 2004 and October 15, 2006. Historically, Children's has done approximately 10 transplants per year; therefore, we will review approximately 15 charts at Children's Healthcare of Atlanta and Sibley Heart Center Cardiology. ;

Study Design

Time Perspective: Retrospective

Related Conditions & MeSH terms

Congenital Disorders

Clinical Trial Details

NCT number	NCT00486057
Study type	Observational
Source	Children's Healthcare of Atlanta
Contact
Status	Terminated
Phase	N/A
Start date	August 2004
Completion date	November 2007

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