Clinical Trials Logo
  1. Home
  2. Congenital Diaphragmatic Hernia
  3. NCT04583644

Pilot Trial of Fetoscopic Endoluminal Tracheal Occlusion (FETO) in Severe Left Congenital Diaphragmatic Hernia (CDH)

Congenital Diaphragmatic Hernia Clinical Trial

Official title:
Pilot Trial of Fetoscopic Endoluminal Tracheal Occlusion (FETO) in Severe Left Congenital Diaphragmatic Hernia (CDH)

Clinical Trial Summary

Despite advances in prenatal diagnosis and postnatal therapies, including ECMO (Extracorporeal Membrane Oxygenation), inhaled nitric oxide therapy, and ventilator strategies that minimize ventilator-induced lung injury, morbidity and mortality rates for babies with severe CDH remain high. The rationale for fetal therapy in severe CDH is to promote adequate lung growth for neonatal survival. Prenatal tracheal occlusion obstructs the normal egress of lung fluid during pulmonary development leading to increased lung tissue stretch, increased cell proliferation, and accelerated lung growth. The investigator's goal with this pilot study is to study the feasibility of implementing Fetoscopic Endoluminal Tracheal Occlusion (FETO) therapy in the most severe group of fetuses with left CDH (LHR O/E < 25%).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04583644
Study type Interventional
Source University of California, San Francisco
Contact Katie Archbold, BA
Phone 415-476-0445
Email fetus@ucsf.edu
Status Recruiting
Phase N/A
Start date October 2, 2020
Completion date April 2028
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT05100693 - Smart Removal for Congenital Diaphragmatic Hernia N/A
Recruiting NCT05450653 - Trial of FETO for Severe Congenital Diaphragmatic Hernia N/A
Terminated NCT04140669 - Automated Myocardial Performance Index Using Samsung HERA W10
Recruiting NCT05201144 - A Trial of Phosphodiesterase-5 Inhibitor in Neonatal Congenital Diaphragmatic Hernia (TOP-CDH) Phase 2
Not yet recruiting NCT06281717 - Fetal Endotracheal Occlusion (FETO) in Fetuses With Severe Congenital Diaphragmatic Hernia N/A
Recruiting NCT04429750 - Intact Cord Resuscitation in CDH N/A
Recruiting NCT03750266 - 3D Animation and Models to Aid Management of Fetal CDH
Not yet recruiting NCT05421676 - Fetal Endoscopic Tracheal Occlusion for CDH (CDH) N/A
Completed NCT01243229 - Genetic Analysis of Congenital Diaphragmatic Disorders
Completed NCT03314233 - Delayed Cord Clamping for Congenital Diaphragmatic Hernia N/A
Recruiting NCT04114578 - Exploratory Observational Prospective Study in Neonatal and Pediatric Congenital Diaphragmatic Hernia
Completed NCT03666767 - Management and Outcomes of Congenital Anomalies in Low-, Middle- and High-Income Countries
Recruiting NCT02986087 - Feto-Endoscopic Tracheal Occlusion (FETO) for Left Congenital Diaphragmatic Hernia N/A
Recruiting NCT03674372 - Fetoscopic Endoluminal Tracheal Occlusion N/A
Active, not recruiting NCT05839340 - Neurally Adjusted Ventilatory Assist for Neonates With Congenital Diaphragmatic Hernias N/A
Enrolling by invitation NCT05962346 - Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia N/A
Withdrawn NCT04186039 - Functional Evaluation of the Fetal Lung by Functional Magnetic Resonance Imaging - Blood Oxygenation Level Dependent (MRI-BOLD), in Congenital Diaphragmatic and Parietal Malformations N/A
Unknown status NCT01302977 - Fetal Tracheal Occlusion in Severe Diaphragmatic Hernia: a Randomized Trial Phase 2
Recruiting NCT03179371 - Proteomic Profiling for Congenital Diaphragmatic Hernia
Recruiting NCT03138863 - Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia (FETO) N/A