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Brain Indices of Stimulant Treatment in Drug-Naive Youth at Risk for Substance Use Disorder

Substance Abuse Clinical Trial

Official title:
Brain Indices of Stimulant Treatment in Drug-Naive Youth at Risk for Substance Use Disorder

Clinical Trial Summary

Childhood ADHD and comorbid oppositional defiant disorder (ODD) and conduct disorder (CD) are considered risk factors for subsequent substance abuse, and youth with both ADHD and ODD/CD are at greatest risk. However, the effects of treatment of ADHD with stimulant medications such as methylphenidate (MPH) and mixed amphetamine salts (MAS) on risk for substance abuse are poorly understood. The study team propose to use fMRI to study the effects of extended release mixed amphetamine salts (MAS-XR) in drug-naïve youth 7-12 years at low risk (i.e., ADHD only) and high risk (i.e., ADHD + ODD/CD) for substance abuse on the brain reward system, to better understand the potential impact of these medications on an aspect of brain functioning which is thought to underlie vulnerability to substance abuse.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04170738
Study type Interventional
Source Icahn School of Medicine at Mount Sinai
Contact Jeffrey Newcorn, MD
Phone 212-659-8775
Email jeffrey.newcorn@mssm.edu
Status Recruiting
Phase Phase 4
Start date November 5, 2019
Completion date April 2024
View Details
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