Investigating Psychosocial Intervention Treatment Response in

Status Completed

Clinical Trial Summary

This research focuses on youth with conduct disorder (CD), and a history of violence. CD is a youth neurodevelopmental disorder that is commonly associated with criminality. Although psychosocial interventions that address impulsivity and self-control have been shown to be effective at helping promote prosocial behavior in patients with CD, the biological changes that occur as a result of treatment are not well understood. This study will explore changes in the brain function of the anterior cingulate cortex (ACC) in response to a common psychosocial intervention (Stop, Now and Plan). This study will contribute to our understanding of biological mechanisms involved in therapeutic gains among children with behavioural problems and youth offenders; therefore, it will inform further development of treatment programs for children/youth with impulsive behaviours.

Clinical Trial Description

CD is a youth-limited neurodevelopmental disorder characterized by impulsivity and dysfunctional social behavior. CD is associated with increased risks of mortality, lower educational and occupational achievement, criminal behavior and other psychosocial difficulties, and hence presents a significant burden to society. Impulsivity is a prominent predictor of violence in CD. Treatment programs targeting impulsivity in CD have been shown to be effective at increasing pro-social functioning in CD, but the biological mechanisms that underpin these therapeutic gains are not well understood. Past research suggests that the ACC play a role in CD and impulsivity. This study explores biological and behavioral changes in response to Stop, Now and Plan (SNAP), a validated 13-week psychosocial intervention addressing impulsivity and self-control in youth. The main hypotheses are: (1) CD youth who respond to SNAP treatment will exhibit greater post-treatment ACC activation during an fMRI imaging task compared with their baseline, pre-treatment ACC activation. The secondary hypotheses are: (1) CD youth will exhibit lower ACC activation at baseline during an fMRI imaging task compared with the baseline ACC activation exhibited by typically developing youth. ;

Study Design

Related Conditions & MeSH terms

Conduct Disorder

Clinical Trial Details

NCT number	NCT02998073
Study type	Interventional
Source	Centre for Addiction and Mental Health
Contact
Status	Completed
Phase	N/A
Start date	October 15, 2017
Completion date	August 11, 2021

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03535805` - Transdiagnostic, Cognitive and Behavioral Intervention for in School-aged Children With Emotional and Behavioral Disturbances	N/A
Recruiting	`NCT05449002` - Digital Single Session Intervention for Youth Mental Health	N/A
Withdrawn	`NCT02247986` - Investigating the Impact of Methylphenidate on Neural Response in Disruptive Behavioral Disorder	Phase 1/Phase 2
Recruiting	`NCT04631042` - Developing Brain, Impulsivity and Compulsivity
Completed	`NCT02485587` - Arousal-Biofeedback for the Treatment of Aggressive Behavior in Children and Adolescents	N/A
Completed	`NCT00819429` - Supplements and Social Skills Intervention Study	N/A
Completed	`NCT00626236` - Phase 2a Study of Safety and Tolerability of SPN-810 in Children With ADHD and Persistent Serious Conduct Problems	Phase 2
Completed	`NCT01085305` - The Effectiveness of Parent-Child Interaction Therapy (PCIT)	N/A
Completed	`NCT00000385` - Long-Term Lithium Treatment for Aggressive Conduct Disorder	Phase 3
Completed	`NCT00250354` - A Study of the Safety and Effectiveness of Risperidone for the Treatment of Conduct Disorder and Other Disruptive Behavior Disorders in Children Ages 5 to 12 With Mild, Moderate, or Borderline Mental Retardation	Phase 3
Withdrawn	`NCT01443949` - Teenagers, Drug Addiction, and Reward and Impulse Control
Completed	`NCT04091633` - School Health Implementation Network: Eastern Mediterranean	N/A
Completed	`NCT02563145` - Real-time fMRI for the Treatment of Aggressive Behavior in Adolescents	N/A
Completed	`NCT02766101` - Manville Moves: an Exercise Intervention for Behavioral Regulation Among Children With Behavioral Health Challenges	N/A
Completed	`NCT00404911` - Multi-Family Group Therapy for Reducing Behavioral Difficulties in Youth	N/A
Completed	`NCT00051727` - Prevention of School Dropout for Mexican American Adolescents	Phase 2
Completed	`NCT03292848` - Trial to Assess the Pharmacokinetics, Safety, Tolerability of Oral Brexpiprazole in Children (6 to <13 Years Old) With Central Nervous System Disorders	Phase 1
Recruiting	`NCT05637320` - Big Feelings: A Study on Children's Emotions in Therapy	N/A
Recruiting	`NCT04170738` - Brain Indices of Stimulant Treatment in Drug-Naive Youth at Risk for Substance Use Disorder	Phase 4
Completed	`NCT01822392` - On-line Treatment for Conduct Problems	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Investigating Psychosocial Intervention Treatment Response in Justice-Involved Youth With Conduct Disorder

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms