View clinical trials related to Conduct Disorder.
Filter by:The primary purpose of this study is to develop a mobile health (mHealth) application that will both advance theory in and clinical practice of homework (HW) implementation. The mobile health application will enhance the existing evidence informed curriculum of a Multiple Family Group model (called 4 Rs and 2 Ss for Strengthening Families Model) for families with children who have disruptive behavior disorders. This mobile application consists of two primary components that will support engagement and integration of the model's core concepts in family life. The first component focuses on delivering homework via a highly engaging, multiplayer, interactive, cooperative, and skill-building game platform aimed at improving the "Design" and "Do" process of homework.The second component focuses on targeting factors putatively related to poor HW implementation within the "Do" process.
Background: - Disruptive behavior is a common problem for children and adolescents. It can be treated with some success with stimulant medicine. Researchers want to learn more about how this works. Objective: - To learn how the brain changes when taking the medicine methylphenidate for behavior problems. Eligibility: - Children ages 10 17 with conduct disorder and/or attention deficit disorder. - Healthy volunteers the same age. Design: - Participants will be screened under a separate protocol. - Participants will have two 3-hour sessions at the clinic. Girls who are menstruating will have a pregnancy test before their scans. - Visit 1: All participants will: - Perform simple tests on a computer. - Fill out a questionnaire along with their parent or guardian. - Have an MRI scan. A magnetic field and radio waves take pictures of the brain. Participants will lie on a table that slides into a metal cylinder. A coil will be placed over their head. They will be in the scanner for 60 minutes, lying still or performing a simple task. They will practice the task before the scan. A computer screen will show them task information during the scan. The scanner makes loud knocking sounds. Participants will get earplugs. Their parent or guardian can stay with them during the scan. - Only participants with behavior disorders will: - Take a pill of the study medicine or placebo. - Be monitored for any side effects. - Visit 2 is a repeat of Visit 1, except participants who got a pill in Visit 1 will get the other pill in Visit 2. For healthy volunteers, the 2 visits are exactly the same.
Background: - The risk for becoming addicted to drugs varies from person to person, even among those who use similar drugs in a similar way. Studies suggest that certain personality traits seen in people with drug addiction may be present before drug use. These traits include responding differently to rewards or impulsivity. Early use of drugs (before age 15) is also associated strongly with drug addiction later in life. Researchers want to study teenagers with and without certain behavioral problems, including those who have used drugs and those who have not. This may help them better understand behaviors that might predict future drug addiction. Objectives: - To understand brain function in teenagers who may be at a higher risk than others to drug addiction. Eligibility: - Teenagers between 13 and 17 years of age who fit into one of four groups: - Have never or rarely used drugs - Have never or rarely used drugs and have conduct or behavior disorders - Have used drugs on many occasions - Have used drugs on many occasions and have conduct or behavior disorders Design: - Participants will be screened with a medical history, and physical and neurological exams. They will also have blood and urine tests. Participants will answer questions about past drug use and any current medications. They will also have a breathalyzer and carbon monoxide breath test to check for recent drug and alcohol use. - This study requires four visits to the clinical center for magnetic resonance imaging (MRI) scans and other tests. - The first study visit will include training for the MRI scans. Participants will practice the tasks in front of a computer and in a mock (fake) MRI machine. Participants will also be asked several questions about their personality and past experiences. - Researchers will test changes to tryptophan and dopamine levels. Both of these chemicals affect decision making and brain function. On the three study visits, participants will have the following tests in a randomly selected order. One study will be done at each visit. - MRI scans with changes to dopamine and tryptophan levels - MRI scans with changes to dopamine only (with placebo) - MRI scans with changes to tryptophan only (with placebo) - Participants will be monitored with frequent blood draws and other tests during the study visits....