Hypospadias Clinical Trial
Official title:
A Prospective Registry of Patients With Congenital Penile Anomalies
Prospective registry and biobank in pediatric patients with congenital penile anomalies
According to the U.S. Center for Disease Control and Prevention, in the United States, one in 200 babies is born with congenital penile anomalies. In Korea, there is a rapid increase rate among other types of congenital anomalies from 1993 to 2010, from 0.7 to 10,000 to 9.9 per 10,000 cases. It leaves long term sequelae into adulthood even after the corrective operation has been performed. Some of the sequelae that patients experienced were difficulties in micturition, dissatisfaction with the appearance of the penis, and decreased sexual function, as well as psychosexual well-being. Despite its high prevalence, hypospadias and related penile anomalies have no specific known etiology and mechanisms. However, numerous studies have shown that both gene and environment play a significant role in making etiologies multifactorial. Furthermore, a molecular trial shows that both genetics and environmental factors disrupt the normal development course of the phallus, or penis. Penis formation, growth, or the formation of the male urogenital system, in general, have shown to be androgen dependent. Any defect in the androgen synthesis leading to androgen deficiency or receptors may play a role, specifically, in the development of penile anomalies. Pediatric patients between the ages of 0 to 18 years, with congenital penile anomalies and scheduled to undergo penoplasty will be enrolled. In this prospective observational study, our aims are to collect dartos fascia, which is a tissue in penile region, and examine histochemistry of the sample. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT02752308 -
Effectiveness of Caudal Epidural Block on Intraoperative Blood Loss During Hypospadias Repair
|
Phase 2/Phase 3 | |
Completed |
NCT04239066 -
Penile Ischemia for Hypospadias Repair and The Patients and Surgeons Reported Outcomes
|
N/A | |
Not yet recruiting |
NCT03698721 -
Urothelium Tissue Engineering Using Biopsies From Transurethral Resection of Prostate
|
||
Completed |
NCT03677453 -
Interactive Perioperative Teaching Platform (IPTP)
|
N/A | |
Terminated |
NCT04826484 -
Opioid Reduction Initiative During Outpatient Pediatric Urologic Procedures Using Exparel
|
Phase 3 | |
Completed |
NCT02103712 -
Long Term Outcome of Hypospadias Repair
|
||
Suspended |
NCT05093166 -
Clinical Trial to Assess the Safety and Efficacy of Investigational Product in Patients Due to Hypospadias Treatment Failure
|
Phase 1/Phase 2 | |
Withdrawn |
NCT01762007 -
The Change of the Detrusor Thickness After Hypospadias Repair - Comparison With the Normal Control Group
|
||
Not yet recruiting |
NCT05569863 -
Identification of Hypospadias Parameters Using Digital Photography and Artificial Intelligence
|
||
Completed |
NCT02495090 -
Hypospadias and Exome: Identification of New Genes for Familial Hypospadias
|
N/A | |
Completed |
NCT04668183 -
Ultrasound-guided PNB and DPNB for Pediatric Distal Hypospadias Surgery
|
||
Completed |
NCT01370798 -
Local Oestrogen Versus Placebo as Preoperative Treatment in Patients With Severe Hypospadias: Effects on Post-operative Complications
|
Phase 3 | |
Recruiting |
NCT06417060 -
Caudal Anesthesia Versus Local Anesthesia in Hypospadias
|
N/A | |
Active, not recruiting |
NCT02861950 -
Does Caudal Block Increase the Incidence of Urethrocutaneous Fistula Formation Following Hypospadias Repair in Infants?
|
Phase 4 | |
Not yet recruiting |
NCT06410482 -
Analgesia in Pediatric Hypospadias Surgeries
|
N/A | |
Terminated |
NCT02162810 -
Effect of Steroids on Post-Operative Complications Following Proximal Hypospadias Repair
|
N/A | |
Recruiting |
NCT05837000 -
Dexmedetomidine, Ketamine and Magnesium Sulphate in Caudal Block for Hypospadias Repair
|
Phase 4 | |
Recruiting |
NCT05319782 -
Long-term Assesment of Patients Operated for Hypospadias in Their Childhood : Urinary, Aesthetical, Sexual and Psycho-social Consequences
|
N/A | |
Recruiting |
NCT05032222 -
The Role of "Hypospadias Objective Scoring Evaluation" (HOSE) and Uroflowmetry in Evaluation of Successful Hypospadias Repair
|
||
Completed |
NCT05144659 -
Evaluation of Double Faced Transverse Preputial Onlay Island Flap for Hypospadias Repair in Pediatrics
|
N/A |