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Compulsive Behavior clinical trials

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NCT ID: NCT02051192 Completed - Clinical trials for Obsessive-compulsive Disorder

Brief Behavioral Treatment for Anxiety in Young Children

PLET
Start date: January 2014
Phase: Phase 1/Phase 2
Study type: Interventional

Behaviorally and cognitive-behaviorally based therapeutic techniques (BT; CBT) that incorporate exposure therapy useful for treatment of anxiety disorders among typically developing children. Although a large amount of data demonstrate the effectiveness of of BT and CBT approaches for treating anxious youth, there is a gap in the literature for the effectiveness of these approaches for children under the age of seven. Evidence increasingly suggests that family factors such as accommodation and parenting style contribute significantly to the presence of anxiety symptoms as well as treatment outcomes, particularly in young children. These findings stress the importance of using a treatment approach in which parents are directly involved in education, parent training, and generalization of treatment effects. Therefore, this study aims to evaluate a new treatment program, parent-led behavioral treatment, for children ages 3 to 7 years of age who have a principal anxiety disorder diagnosis.

NCT ID: NCT02018848 Completed - Clinical trials for Obsessive-Compulsive Disorder

Internet-delivered Attention Training for Obsessive-Compulsive Disorder

Start date: October 2013
Phase: N/A
Study type: Interventional

The goal of this study is to investigate an attention training program for participants with Obsessive-Compulsive Disorder. The attention training consists of a modified dot probe task with picture stimuli related to washing and checking paired with neutral pictures. Participants are randomly assigned to an experimental and a placebo-control group. After a minimum of 4 weeks of attention training we expect to find differences between participants of the experimental and the control group in terms of attention bias, OCD symptoms, anxiety and depression.

NCT ID: NCT01985815 Completed - Clinical trials for Obsessive-Compulsive Disorder

Refining the Target for Deep Brain Stimulation (DBS) in Severe, Treatment Refractory Obsessive Compulsive Disorder (OCD)

Start date: March 2008
Phase: Phase 1/Phase 2
Study type: Interventional

In select, therapy resistent patients with Obsessive Compulsive Disorder (OCD) Deep Brain Stimulation (DBS) has been used as a treatment. DBS is a therapy modality in which electrodes are implanted within specific sub-structures of the brain in order to modulate the activity in targeted neural circuits associated with different neurological disorders. The results of this novel approach to psychiatric disorders have been optimistic. This study aims to investigate wether or not the distance to target location has an influence on the outcome. In order to deliver DBS, leads containing four electrodes are implanted into the brain target in the ventral capsule/ventral striatum (VC/VS). After an optimization period, patients enter a triple blind randomised two fazed crossover design of two periods of three months. In both crossover branches, patients, evaluating psychiatrist and psychologist are blinded for the stimulation conditions. These conditions are stimulation ON (at optimal parameters) and stimulation OFF. Stimulation parameters are constant during the entire period. During the second crossover branch, stimulation conditions are reversed for all patients.

NCT ID: NCT01813019 Completed - Clinical trials for Patient Diagnosed With OCD

Study to Evaluate the Effect of AFQ056 in Obsessive Compulsive Disorder (OCD) Patients Resistant to Selective Serotonin Reuptake Inhibitor (SSRI) Therapy

Start date: February 2013
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine whether AFQ056 as an add on therapy to SSRIs can have beneficial effects by reducing the total score of Y-BOCS (Yale and Brown Obsessive Compulsive Scale) in OCD patients resistant to SSRI treatment (failed SSRI over 12 weeks at appropriate doses).

NCT ID: NCT01809990 Completed - Clinical trials for Obsessive-Compulsive Disorder

Internet-delivered CBT for Adolescents With Obsessive-Compulsive Disorder - a Pilot Study

Start date: January 2013
Phase: N/A
Study type: Interventional

The main goal of this trial is to study the feasibility and effectiveness of internet-delivered cognitive behavior therapy for adolescents with obsessive-compulsive disorder.

NCT ID: NCT01807403 Completed - Clinical trials for Obsessive-Compulsive Disorder

Comparison of DBS Targets in Obsessive-compulsive Disorder

PRESTOC2
Start date: October 2010
Phase: Phase 3
Study type: Interventional

Deep brain stimulation (DBS) has been proposed for severe and resistant obsessive-compulsive disorder. This electrical stimulation has been tested on, and shown to be effective at, different targets (subthalamic nucleus, caudate nucleus & nucleus accumbens). However, the efficacies of each target have never been compared directly. This protocol aims to do so, with the hypothesis that subthalamic (STN) stimulation will be more efficacious.

NCT ID: NCT01708226 Completed - Clinical trials for Obsessive Compulsive Disorder

Attention Training for Childhood Obsessive Compulsive Disorder: An Open Case Series

AMPOCD
Start date: November 2012
Phase: Phase 1
Study type: Interventional

Pediatric Obsessive Compulsive Disorder (OCD) is a chronic, impairing condition that accrues significant concurrent and long-term risk to affected youth. Although empirically supported psychosocial and pharmacological treatments for OCD exist, many children and their families are not able to adequately access these treatments or derive only partial benefit from them. Such findings highlight the importance of developing more effective treatment options which have the potential to be widely accessible to OCD youth. The investigators are proposing to test a computerized attention modification program, AMP, in six youth with OCD in an open case series to gather information regarding protocol acceptability, feasibility and preliminary efficacy. This phase includes the development and refinement of stimuli selection procedures, behavior avoidance task, EEG protocol, and AMP parameters for use with children. Following ascertainment of study eligibility, participants will undergo a baseline assessment consisting of a clinical interview, neurocognitive assessments, EEG, attention bias assessment, and self report questionnaires. Study participants will then receive 12 sessions of AMP treatment over the course of three weeks. All youngsters and their families will be reassessed at treatment endpoint (week 4). Participation will take a total of about 24 hours over the course of six weeks. Participants who are treatment responders may be asked to return approximately 3 months after completing treatment for a follow-up assessment. Preliminary hypotheses: 1) AMP will be acceptable to youth and families and feasible to administer; 2) Youth receiving AMP will demonstrate decreases in threat bias and OCD symptom severity.

NCT ID: NCT01659125 Completed - Clinical trials for Obsessive-Compulsive Disorder

Effectiveness and Neuropsychological Predictors of Guided Self-Help for Obsessive-Compulsive Disorder (OCD)

Start date: August 2012
Phase: N/A
Study type: Interventional

The primary aim of this study is to learn about who is most likely to benefit from guided self-help (GSH) for obsessive-compulsive disorder (OCD).

NCT ID: NCT01649895 Completed - Clinical trials for Obsessive-compulsive Disorder

D-Cycloserine as an Adjunct to Internet-CBT for OCD

Start date: August 2012
Phase: Phase 4
Study type: Interventional

The purpose of this study is to examine if D-Cycloserine is an effective adjunct to internet-based cognitive behaviour therapy for patients with obsessive-compulsive disorder.

NCT ID: NCT01563003 Completed - Autism Clinical Trials

Cognitive Behavioral Therapy for Anxiety Disorders in Adolescents With Autism

Start date: June 2011
Phase: N/A
Study type: Interventional

Due to the considerable prevalence of anxiety in youth with autism spectrum disorders, this study seeks to establish the efficacy of a modified cognitive behavioral therapy protocol in 50 adolescents versus other available treatment options.