Genetic Testing and Motivational Counseling for FH — GENMOTIV-FH  

Medication Adherence Clinical Trial

Official title: Impact of Genetic Testing and Motivational Counseling on the Adherence to Healthy Lifestyle and Hypolipidemic Therapy and Efficiency of Cascade Screening in Patients With Familial Hypercholesterolemia (GENMOTIV-FH)

Status Recruiting

Clinical Trial Summary

To date, there are highly effective lipid-lowering drugs, the combination of which makes it possible to achieve the target level of LDL-C in most patients with familial hypercholesterolemia (FH). However, the effectiveness of treatment of FH patients strongly depends on adherence to lipid-lowering therapy and to the healthy lifestyle, as well as the detection of the disease and the therapy prescription as early as possible, better in childhood. The aim of the study is to assess the impact of genetic testing and motivational counseling on the effectiveness of treatment and cascade screening in patients with FH.

Clinical Trial Description

There are several tasks of the study:

1. To assess the effect of knowledge of patients with FH about the result of their FH genetic testing on the adherence to a healthy lifestyle and hypolipidemic therapy.

2. To assess the impact of knowledge of patients with FH about the result of their FH genetic testing on the effectiveness of cascade screening.

3. To assess the influence of motivational counseling of patients with FH on the adherence to a healthy lifestyle and hypolipidemic therapy.

4. To assess the impact of motivational counseling of patients with FH on the effectiveness of cascade screening. ;

Related Conditions & MeSH terms

• Adherence
• Adherence, Medication
• Adherence, Patient
• Apolipoprotein B-100, Familial Defective
• Arthrogryposis
• Compliance
• Familial Hypercholesterolemia
• Familial Hypercholesterolemia - Heterozygous
• Familial Hypercholesterolemia With Hyperlipemia
• Genetic Testing
• Hypercholesterolemia
• Hypercholesterolemia, Autosomal Dominant
• Hypercholesterolemia, Autosomal Dominant, 3
• Hypercholesterolemia, Autosomal Dominant, Type B
• Hypercholesterolemia, Familial
• Hypercholesterolemia, Familial, 1
• Hypercholesterolemia, Familial, 2
• Hypercholesterolemia, Familial, 3
• Hypercholesterolemia, Familial, 4
• Hypercholesterolemia, Familial, 4, Autosomal Recessive
• Hyperlipidemias
• Hyperlipoproteinemia Type II
• Hyperlipoproteinemia Type III
• Hyperlipoproteinemias
• Medication Adherence
• Motivational Interviewing
• Patient Adherence
• Patient Compliance
• Therapeutic Adherence
• Therapeutic Adherence and Compliance
• Treatment Adherence
• Treatment Adherence and Compliance

• NCT number: NCT04656028
• Study type: Interventional
• Source: National Medical Research Center for Therapy and Preventive Medicine
• Contact: Alexandra Ershova, MD, PhD
• Phone: +79165598536
• Email: alersh@mail.ru
• Status: Recruiting
• Phase: N/A
• Start date: June 15, 2020
• Completion date: March 30, 2025