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Increasing Community-acquired Pneumonia Protocol Adherence by Antibiotic Stewardship — CAP-PACT  

Community-acquired Pneumonia Clinical Trial

Official title:
Community-acquired Pneumonia: Increasing Protocol Adherence by Antibiotic Stewardship in a Stepped Wedge Cluster- Randomized Trial

Clinical Trial Summary

The purpose of this study is to determine the effect of a multifaceted antibiotic stewardship intervention on protocol adherence of moderate-severe community-acquired pneumonia.

Clinical Trial Description

The purpose of the study is to show a decrease in broad-spectrum antibiotics with a non-inferiority in 90-day mortality. Hospitals with a pre-intervention protocol adherence of >70% are excluded from the primary analysis. Primary analysis will be done with a mixed effects model with a random effects for clusters and time. Crude outcomes and outcomes adjusted for potential confounders will be reported. Primary analysis will be tested one-sided for a decrease in mortality. Secondary analysis to test two-sided for mortality will be performed. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02604628
Study type Interventional
Source UMC Utrecht
Contact
Status Completed
Phase N/A
Start date November 1, 2015
Completion date February 12, 2019
View Details
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