Community-Acquired Infections Clinical Trial
Official title:
Evaluation of the Protective Role of Beta-blockers Prescribed in a Chronic Way on the Arisen of a Severe Septic Syndrome or a Toxic Shock at Patients Having a Community Infection
The severe sepsis (SS) and toxic shock (TS) are both frequent and severe complications of infectious diseases. They are one of the top ten causes of death in industrialized countries. But an eventual protective role of beta-blockers (anti-hypertensive drug) in their occurrence on a community infection has never been studied. The objective of this study is to evaluate this role.
The severe sepsis (SS) and toxic shock (TS) are both frequent and severe complications of
infectious diseases. They are one of the top ten causes of death in industrialized
countries. The adrenergic system is heavily involved in this pathological/physiological
context. If the effect of various therapeutic strategies allowing the care of the SS/TS was
widely estimated, the impact, positive or negative, therapeutic prescribed in the long term
or more punctually - but be that as it may before the arisen of the sepsis - on the
evolution of a community acute infectious pathology towards the SS/TS, had only little
studied.
The main objective of this study is to estimate the possible protective role of a long-term
prescription of a beta-blocker on the arisen of the SS/TS in patients having an acute
infectious pathology of community origin.
The secondary objective will be to estimate, at the patients having developed a SS/TS, the
impact of this long-term prescription of beta-blockers on the mortality in intensive care
unit (ICU).
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Observational Model: Case Control, Time Perspective: Prospective
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