Common Variable Immunodeficiency Clinical Trial
OBJECTIVES: I. Determine whether polyethylene-glycol-conjugated interleukin 2 (PEG-IL-2) can
reduce the number of infections in patients with common variable immunodeficiency.
II. Determine whether this therapy can improve lung functions in these patients with
pulmonary impairment.
PROTOCOL OUTLINE: This is a randomized, open-label study. Patients are randomized to receive
polyethylene-glycol-conjugated interleukin 2 (PEG-IL-2) or placebo.
Patients receive PEG-IL-2 or placebo by subcutaneous injection weekly for 18 months.
Patients maintain a daily diary for 24 months.
Patients are followed every 4 months for 2 years.
Completion date provided represents the completion date of the grant per OOPD records
;
Allocation: Randomized, Masking: Open Label, Primary Purpose: Treatment
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