Failed Retrograde Cholangiopancreatography (ERCP) Stone Extraction:

Status Not yet recruiting

Clinical Trial Summary

Assessment of the differences in stone size and the largest CBD diameter before and after stenting in one or two sessions. Stone clearance and complications were also determined with the ERCP, and factors associated with complete clearance were evaluated in patients with difficult CBD stones (a large [≥ 20 mm] or multiple [≥ 3 sized ≥ 15 mm] CBD stones). And also compared the outcomes with conventional procedure of open surgery.

Clinical Trial Description

Gallstones are a very common problem in developed countries. Most patients with gallstones remain asymptomatic throughout their lifetime, but 10 % - 25 % of them may develop biliary pain or complications, with an annual risk of about 2 % - 3 % for symptomatic disease and 1 % - 2 % for major complications. The development of symptomatic disease and complications is mostly related to the migration of stones into the common bile duct (CBD). Common bile duct stones (CBDSs) may be treated by endoscopic retrograde cholangiopancreatography (ERCP) or surgically during cholecystectomy. Removal of common bile duct (CBD) stones can still be difficult in patients with large or multiple stones despite an adequate sphincterotomy. Procedures such as mechanical, extracorporeal, electrohydraulic or laser lithotripsy, and chemical dissolution have been introduced as effective therapeutic interventions for irretrievable CBD stones. However, these techniques have their drawbacks, are not widely available, or are still under clinical evaluation. Several studies have shown that insertion of an endoscopic biliary stent is a safe, effective, and widely available measure. An indwelling stent provides biliary drainage and fragments large stones, thereby reducing the risk of cholangitis and allowing stones to pass spontaneously or rendering them more extractable at a later procedure. Thus, this study intends to shed a light on advances in diagnosis and management in patients with biliary difficult stones. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05746832
Study type	Interventional
Source	Assiut University
Contact	Zyad Osama Harith, resident
Phone	01149863511
Email	zyadosama200000@gmail.com
Status	Not yet recruiting
Phase	N/A
Start date	September 2024
Completion date	December 2024

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See also
Status	Clinical Trial	Phase
Not yet recruiting	`NCT05823181` - Early Versus Late Laparoscopic Exploration of Common Bile Duct After Failure of Extraction of Common Bile Duct Stones by ERCP
Not yet recruiting	`NCT06071247` - Application and Translational Research of 3D Printed in Treatment of Choledocholithiasis Under ERCP	N/A
Completed	`NCT02349568` - The Cost Effectiveness of Endoscopic Ultrasound ( EUS ) Based Strategy in Diagnosis of Common Bile Duct Stones	N/A
Recruiting	`NCT04410848` - Symbolic Regression Model To Predict Choledocholithiasis
Completed	`NCT05068739` - Needle Knife Fistulotomy Versus Partial Ampullary Endoscopic Mucosal Resection for Difficult Biliary Cannulation	N/A
Completed	`NCT02394327` - Endoscopic Nasogallbladder Drainage Versus Gallbladder Stenting Before Cholecystecomy	N/A
Not yet recruiting	`NCT06011941` - Modified Laparoscopic Transcystic Biliary Drainage in the Management of Cholecystocholedocholithiasis	N/A
Completed	`NCT05186350` - SpyGlass Versus ESWL for Large Common Bile Duct Stones	N/A
Completed	`NCT05639816` - Effect of Common Bile Duct Stone Clearance Using Saline Irrigation After Stone Removal: A Prospective Randomized Control Trial.	N/A
Completed	`NCT03490383` - Study of Microbiota in Bile From Patients With Common Bile Duct Stone During ERCP
Completed	`NCT05901363` - ERCP Plus Laparoscopic Cholecystectomy Versus Laparoscopic Common Bile Duct Exploration and Cholecystectomy	N/A
Completed	`NCT03422042` - Short Duration Versus Fourteen Days Antibiotic in Common Bile Duct Cholangitis	N/A
Recruiting	`NCT05945797` - Effects of Dexamethasone on Common Bile Duct Cannulation Time	N/A
Active, not recruiting	`NCT02189421` - Multibending vs Conventional Endoscope for Direct Peroral Cholangioscopy	N/A
Recruiting	`NCT06092905` - Endoscopic Common Bile Duct Stones Clearance During Pregnancy

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Failed Retrograde Cholangiopancreatography (ERCP) Stone Extraction: Surgical Interference

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms