Heart Arrest Clinical Trial
Official title:
New Predictive Tool of Awakening in Comatose Patients in the Intensive Care Unit
Evaluating the prognosis of comatose patients after cardiac arrest (CA) in the intensive care unit (ICU) remains challenging. It requires a multimodal approach combining standardized clinical examination, serum biomarkers, imaging and classically electrophysiological examinations, (among them auditive evoked potentials or AEP) but none has a sufficient sensitivity/specificity. In a preliminary study, the investigators developed an algorithm from the signal collected with AEP, and generated a probability map to visually classify the participants after the algorithm processing. Participants could be classified either with a good neurological prognosis or with bad neurological prognosis or death. The investigators hypothesize that the "PRECOM" tool, applied blindly to a large prospective multicenter cohort of patients admitted to intensive care for coma in the aftermath of CA will predict neurological prognosis at 3 months with high sensitivity and specificity.
Evaluating the prognosis of comatose participants after cardiac arrest (CA) in the intensive care unit remains challenging. It requires a multimodal approach combining standardized clinical examination, serum biomarkers, imaging and classically electrophysiological examinations: 1 / the electroencephalogram, bad prognosis assessed when the electroencephalogram (EEG) is discontinuous, areactive, monotone,…), 2 / somesthetic evoked potentials, the absence of the N20 cortical wave has a specificity of poor prognosis of 68-100% and 3 / auditory evoked potentials (AEP), the presence of mismatchnegativity (MMN) would be of good prognosis with a specificity up to 90% but rarely performed in current practice. Routinely, these examinations are sometimes difficult to interpret in sedated participants, in an intensive care unit environment that generates numerous artefacts. Above all, all these techniques require the presence of a neurophysiology unit, with few experts available. In a preliminary study, in collaboration with the applied mathematics laboratory of the ENS (Ecole Normale Supérieure), an algorithm was developed from the signal extracted from AEP. A probability map was generated with a software allowing to visually classify the participants after processing signal by the algorithm in a cluster of points with a high specificity into "good neurological prognosis" and "bad neurological prognosis". Neither artifacts or sedation prevented data analysis. The investigators hypothesize that the "PRECOM" tool, applied blindly to a large prospective multicenter cohort of participants admitted to intensive care for coma in the aftermath of a caridiac arrest will predict the neurological prognosis of participants with high sensitivity and specificity. This tool, carried out during the first week of the coma, will be compared to a standardized procedure used routinely by the participating resuscitators. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT04078815 -
End-of-life Practices in 2019 vs. 2014
|
||
Completed |
NCT02816385 -
Study of Myocardial Contractility After Cardiac Surgery Under an Anterograde or Retrograde Cardioplegia
|
N/A | |
Completed |
NCT02486211 -
Amantadine to Speed Awakening After Cardiac Arrest
|
Phase 2 | |
Recruiting |
NCT02326506 -
Evaluation of Drainable Volume Measurements During VA-ELS
|
N/A | |
Completed |
NCT00139542 -
AED Use in Out-of-Hospital Cardiac Arrest: A New Algorithm Named "One Shock Per Minute"
|
Phase 3 | |
Completed |
NCT00004560 -
Public Access Defibrillation (PAD) Community Trial
|
Phase 3 | |
Completed |
NCT00000502 -
Evaluation of SC-V Versus Conventional CPR
|
Phase 3 | |
Completed |
NCT03640949 -
Vasopressin and Methylprednisolone for In-Hospital Cardiac Arrest
|
Phase 2/Phase 3 | |
Completed |
NCT03310450 -
Tour de Borobudur Troponin Study on Predictors and Synergistic Role of MDA and Hs-CRP Levels
|
||
Completed |
NCT02733146 -
Histones and Free-plasma DNA After Cardiac Arrest
|
N/A | |
Withdrawn |
NCT01082991 -
Patient Acuity Rating: a Tool to Prevent In-Hospital Cardiac Arrest
|
Phase 0 | |
Terminated |
NCT00189423 -
ResQ Trial: Impact of an ITD and Active Compression Decompression CPR on Survival From Out-of-Hospital Cardiac Arrest
|
N/A | |
Completed |
NCT00172354 -
Hydrocortisone in Patients of Out-of-hospital Cardiac Arrest
|
N/A | |
Completed |
NCT02858583 -
SI + CC Versus 3:1 C:V Ratio During Neonatal CPR
|
N/A | |
Completed |
NCT03664557 -
Feasibility of REBOA in Refractory Cardiac Arrest
|
N/A | |
Completed |
NCT01968148 -
Mechanisms of Ultra-acute Hyperglycemia After Successful Resuscitation From Out-of-hospital Cardiac Arrest
|
N/A | |
Completed |
NCT00392639 -
Clinical and Economical Interest of Endovascular Cooling in the Management of Cardiac Arrest (ICEREA Study)
|
Phase 4 | |
Recruiting |
NCT06081283 -
Antiseizure Medication in Seizure Networks at Early Acute Brain Injury
|
Phase 4 | |
Completed |
NCT02780050 -
Influence of Core Muscles Activation Using Physical Fitness on the Performance of Chest Compression
|
N/A | |
Withdrawn |
NCT04287842 -
Impact if Desflurane Preconditioning on the Content of the Phospho-GSK-3b in the Rat's Neurons in the Model of I/R
|
Phase 4 |