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VIGABatrin in Post-anoxic STATus Epilepticus - Phase IIa — VIGAB-STAT  

Coma Clinical Trial

Official title:
VIGABatrin in Post-anoxic STATus Epilepticus - Phase IIa

Clinical Trial Summary

This is a pilot trial of a single loading dose of vigabatrin in post-anoxic status epilepticus.

Clinical Trial Description

This pilot trial aims to demonstrate the feasibility of enteral administration of a single load of vigabatrin within targeted 48 hours of post-anoxic status epilepticus onset in unconscious survivors of cardiac arrest undergoing targeted temperature management. The load of VGB is in addition to the load of a commonly used intravenous second-line therapy given at the discretion of the treating neurologist. Serial blood tests will be obtained, including vigabatrin levels, taurine levels, neuron specific enolase, light chain neurofilament, and glial fibrillary acidic protein. In survivors that regain consciousness and survive to follow up, 6 months visual field perimetry will be obtained. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04772547
Study type Interventional
Source University of Florida
Contact
Status Completed
Phase Phase 2
Start date September 22, 2021
Completion date December 31, 2023
View Details
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