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Amantadine to Speed Awakening After Cardiac Arrest — AWAKE  

Heart Arrest Clinical Trial

Official title:
Amantadine to Speed Awakening After Cardiac Arrest

Clinical Trial Summary

This study evaluates if amantadine will increase the rate of awakening in patients resuscitated from cardiac arrest but comatose (not following commands) after their resuscitation. Half of the participants will receive amantadine and the other will receive placebo.

Clinical Trial Description

Amantadine has been used to help patients awaken following traumatic brain injury, but it has not been studied in patients with anoxic brain injury.

Amantadine is a dopamine agonist and may help with stimulating the brain to awaken. The investigators will randomize subjects who remain comatose 72 hours following resuscitation from cardiac arrest to either amantadine or placebo. They will be treated with either amantadine or placebo for 7 days. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02486211
Study type Interventional
Source University of Pittsburgh
Contact
Status Completed
Phase Phase 2
Start date September 2015
Completion date June 30, 2018
View Details
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