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Coma; Prolonged clinical trials

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NCT ID: NCT04921683 Completed - Clinical trials for Traumatic Brain Injury

The Use of LIFUP in Chronic Disorders of Consciousness

Start date: June 21, 2021
Phase: N/A
Study type: Interventional

When patients survive a severe brain injury but fail to fully recover, they often enter a Disorder of Consciousness (DoC) --that is, a set of related conditions of decreased awareness and arousal including the Vegetative State (VS) and the Minimally Conscious State (MCS). When these conditions become chronic, there are no approved treatments to help bolster any further recovery. In prior work, we have shown the clinical feasibility and potential of Low Intensity Focused Ultrasound Pulsation (LIFUP) as a remarkably safe form of non-invasive brain stimulation in these conditions.

NCT ID: NCT03443037 Recruiting - Amantadine Clinical Trials

Benefits of Amantadine in Patients With Coma State

Start date: March 1, 2016
Phase:
Study type: Observational

The study was a single center observational-prospective study and approved by local ethics committee. Patients in coma state due to traumatic brain injury, cardiac arrest or ischemic stroke who are older than 18 years of age were included in the study. Patients who received amantadine 200mg/day for fourteen days according to ICU protocols decided by primary physician formed the amantadine group, and the rest of the subjects were included in the control group. All patients were evaluated for Glasgow Coma Score, JFK Coma Recovery Scale and Disability Rating Scale once a week for three months.