Colorectal Tumors Clinical Trial
Official title:
A Pilot Study to Determine Fructose Uptake by Primary Human Colorectal Tumors
This proposed study is designed to investigate the specific uptake of fructose by human colorectal tumors. In this study, subjects with colorectal cancer undergoing surgery will receive an oral sugar solution containing fructose or xylose prior to surgery. The tumor will then be resected, and a portion of the tissue will be used to measure the abundance of fructose and xylose. The study hypothesis is that the tumors will take up fructose sugar but not xylose sugar. A comparison of the sugar uptake between the tumor and normal tissues from the adjacent intestinal epithelium and smooth muscle and the liver will be conducted. This proposal will confirm that human colorectal cancer tumors can directly absorb dietary sugars, which has never been demonstrated.
Status | Recruiting |
Enrollment | 12 |
Est. completion date | December 31, 2023 |
Est. primary completion date | December 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Subjects of 18 years of age or older, male, and female - Subjects with a diagnosis of invasive non-hereditary colonic adenocarcinoma who will be undergoing standard of care (SOC) laparoscopic, robot-assisted, or open surgical resection - The subject provides informed consent Exclusion Criteria: - Subjects with a history of uncontrolled diabetes mellitus (A1C >7.0) Type I and Type 2, will be excluded to avoid potential confounders associated with the consumption of a large bolus of sugar (e.g., hyperglycemia and hyperinsulinemia) - Inflammatory Bowel Disease (Ulcerative Colitis or Crohn's Disease) - Patients on steroid medications - Patients with current infectious disease - Subjects who do not speak English |
Country | Name | City | State |
---|---|---|---|
United States | Weill Cornell Medicine | New York | New York |
Lead Sponsor | Collaborator |
---|---|
Weill Medical College of Cornell University |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The abundance of fructose in tumor extracts | The abundance of fructose in tumor extracts assessed by mass spectrometry in the morning after the consumption of oral sugar solutions. | Morning after the consumption of oral sugar solutions(during surgery at the time of specimen removal) | |
Secondary | The abundance of Fructose and [13C]-Fructose in the blood | The abundance of Fructose and [13C]-Fructose in the blood in the morning after the consumption of oral sugar solutions assessed by mass spectrometry. | Morning after the consumption of oral sugar solutions(during surgery at the time of specimen removal) | |
Secondary | Abundance of Fructose and [13C]-Fructose in the urine | The abundance of Fructose and [13C]-Fructose in the urine in the morning after the consumption of oral sugar solutions assessed by mass spectrometry. | Morning after the consumption of oral sugar solutions(during surgery at the time of specimen removal) | |
Secondary | Abundance of Fructose and [13C]-Fructose in the liver | The abundance of Fructose and [13C]-Fructose in the liver tissue in the morning after the consumption of oral sugar solutions assessed by mass spectrometry. | Morning after the consumption of oral sugar solutions(during surgery at the time of specimen removal) | |
Secondary | Abundance of Fructose and [13C]-Fructose in the intestine | The abundance of Fructose and [13C]-Fructose in the intestine tissue in the morning after the consumption of oral sugar solutions assessed by mass spectrometry. | Morning after the consumption of oral sugar solutions(during surgery at the time of specimen removal) | |
Secondary | Abundance of Fructose and [13C]-Fructose in the mesentery tissues | The abundance of Fructose and [13C]-Fructose in the mesentery tissue in the morning after the consumption of oral sugar solutions assessed by mass spectrometry. | Morning after the consumption of oral sugar solutions(during surgery at the time of specimen removal) | |
Secondary | The abundance of Xylose and [13C]-Xylose in the blood | The abundance of Xylose and [13C]-Xylose in the blood in the morning after the consumption of oral sugar solutions assessed by mass spectrometry. | Morning after the consumption of oral sugar solutions(during surgery at the time of specimen removal) | |
Secondary | The abundance of Xylose and [13C]-Xylose in the urine | The abundance of Xylose and [13C]-Xylose in the urine in the morning after the consumption of oral sugar solutions assessed by mass spectrometry. | Morning after the consumption of oral sugar solutions(during surgery at the time of specimen removal) | |
Secondary | The abundance of Xylose and [13C]-Xylose in the liver | The abundance of Xylose and [13C]-Xylose in the liver tissue in the morning after the consumption of oral sugar solutions assessed by mass spectrometry. | Morning after the consumption of oral sugar solutions(during surgery at the time of specimen removal) | |
Secondary | The abundance of Xylose and [13C]-Xylose in the intestinal tissue | The abundance of Xylose and [13C]-Xylose in the intestinal tissue in the morning after the consumption of oral sugar solutions assessed by mass spectrometry. | Morning after the consumption of oral sugar solutions(during surgery at the time of specimen removal) | |
Secondary | The abundance of Xylose and [13C]-Xylose in the mesentery tissues | The abundance of Xylose and [13C]-Xylose in the mesentery tissues in the morning after the consumption of oral sugar solutions assessed by mass spectrometry. | Morning after the consumption of oral sugar solutions(during surgery at the time of specimen removal) | |
Secondary | The abundance of Xylose and [13C]-Xylose in the in the tumor | The abundance of Xylose and [13C]-Xylose in the tumor in the morning after the consumption of oral sugar solutions assessed by mass spectrometry. | Morning after the consumption of oral sugar solutions(during surgery at the time of specimen removal) |
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