Colorectal Surgery Clinical Trial
Official title:
Phase 2 Study of One Dose Prophylactic Antibiotic in Laparoscopic Colorectal Surgery
Verified date | December 2011 |
Source | National Cancer Center, Korea |
Contact | n/a |
Is FDA regulated | No |
Health authority | Korea: Institutional Review Board |
Study type | Interventional |
In colorectal surgery, the use of prophylactic antibiotics is recommended. The standard use
of antibiotics for colorectal surgery is three doses.
It has been reported that the surgical site infection rates of laparoscopic colorectal
surgery are lower than open colorectal surgery. However, the evidence of proper application
of antibiotic for laparoscopic colorectal surgery is still not enough.
The investigators are researching the efficacy and safety of one dose prophylactic
antibiotic in laparoscopic colorectal surgery.
Status | Completed |
Enrollment | 312 |
Est. completion date | December 2011 |
Est. primary completion date | December 2011 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years to 80 Years |
Eligibility |
Inclusion Criteria: - Patients have laparoscopic colorectal surgery for cancer at National Cancer Center - Patients should sign a written informed consent - Age between 18-80 years - Adequate bone marrow function Hb = 10g/dl (after treatment for simple iron deficiency anemia) WBC = 3,000/mm3 PLT = 100,000/mm3 - Adequate kidney function Creatinine = 1.5 mg/dl - No remarkable evidence of heart dysfunction and lung dysfunction Exclusion Criteria: - Patients undergo emergency surgery with multiple symptoms - Open colorectal surgery for cancer or conversion to an open procedure - Patients who undergo only ostomy surgery - Palliative surgery - Surgery combined with other organs - Patients on treatment with recurred cancer - Patients who have active bacterial infection and required parenteral antibiotics - Patients have an allergy to Cefoxitin - Other organ cancer history(except who had radical excision for skin cancer) - Presence of other serious disease - Mentally ill patients - Legally unable to participate in clinical trial - Lactating or pregnant women - Patients who will obviously fail to regular follow-up visit or will be off study voluntarily - Not eligible to participate for other reasons by doctor's decision |
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Korea, Republic of | National Cancer Center Hospital | Goyang | Gyeonggi-do |
Lead Sponsor | Collaborator |
---|---|
National Cancer Center, Korea |
Korea, Republic of,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Surgical site infection | any surgical infections (superficial incisional infection or infection of deep incision space or organ space infection) | Three weeks after surgery | Yes |
Secondary | Overall infection | Overall infection including surgical site infection, pneumonia, urinary tract infection etc. | Three weeks after surgery | Yes |
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