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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT01220661
Other study ID # NCCCTS-10-485
Secondary ID
Status Completed
Phase Phase 2
First received October 12, 2010
Last updated December 11, 2011
Start date October 2010
Est. completion date December 2011

Study information

Verified date December 2011
Source National Cancer Center, Korea
Contact n/a
Is FDA regulated No
Health authority Korea: Institutional Review Board
Study type Interventional

Clinical Trial Summary

In colorectal surgery, the use of prophylactic antibiotics is recommended. The standard use of antibiotics for colorectal surgery is three doses.

It has been reported that the surgical site infection rates of laparoscopic colorectal surgery are lower than open colorectal surgery. However, the evidence of proper application of antibiotic for laparoscopic colorectal surgery is still not enough.

The investigators are researching the efficacy and safety of one dose prophylactic antibiotic in laparoscopic colorectal surgery.


Description:

In colorectal surgery, the use of prophylactic antibiotics is recommended. The standard use of antibiotics for colorectal surgery is three doses.

One randomized controlled study reported that surgical site infection rates of three doses prophylactic antibiotics are lower than those of one dose in colorectal surgery (4.3 versus 14.2%). But, surgical site infection rates between one dose and three doses were not different in laparoscopic subgroup of this study (11 versus 11%)

It has been reported that the surgical site infection rates of laparoscopic colorectal surgery are lower than open colorectal surgery. However, the evidence of proper application of antibiotic for laparoscopic colorectal surgery is still not enough.

The investigators are researching the efficacy and safety of one dose prophylactic antibiotic in laparoscopic colorectal surgery.


Recruitment information / eligibility

Status Completed
Enrollment 312
Est. completion date December 2011
Est. primary completion date December 2011
Accepts healthy volunteers No
Gender Both
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria:

- Patients have laparoscopic colorectal surgery for cancer at National Cancer Center

- Patients should sign a written informed consent

- Age between 18-80 years

- Adequate bone marrow function Hb = 10g/dl (after treatment for simple iron deficiency anemia) WBC = 3,000/mm3 PLT = 100,000/mm3

- Adequate kidney function Creatinine = 1.5 mg/dl

- No remarkable evidence of heart dysfunction and lung dysfunction

Exclusion Criteria:

- Patients undergo emergency surgery with multiple symptoms

- Open colorectal surgery for cancer or conversion to an open procedure

- Patients who undergo only ostomy surgery

- Palliative surgery

- Surgery combined with other organs

- Patients on treatment with recurred cancer

- Patients who have active bacterial infection and required parenteral antibiotics

- Patients have an allergy to Cefoxitin

- Other organ cancer history(except who had radical excision for skin cancer)

- Presence of other serious disease

- Mentally ill patients

- Legally unable to participate in clinical trial

- Lactating or pregnant women

- Patients who will obviously fail to regular follow-up visit or will be off study voluntarily

- Not eligible to participate for other reasons by doctor's decision

Study Design

Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment


Related Conditions & MeSH terms


Intervention

Drug:
Cefotetan
preoperative one dose prophylactic antibiotic (2g iv, within 1 hour before skin incision)

Locations

Country Name City State
Korea, Republic of National Cancer Center Hospital Goyang Gyeonggi-do

Sponsors (1)

Lead Sponsor Collaborator
National Cancer Center, Korea

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type Measure Description Time frame Safety issue
Primary Surgical site infection any surgical infections (superficial incisional infection or infection of deep incision space or organ space infection) Three weeks after surgery Yes
Secondary Overall infection Overall infection including surgical site infection, pneumonia, urinary tract infection etc. Three weeks after surgery Yes
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