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High-Risk Factors in Patients With Colorectal Polyps a Prospective Case-Control Study

Colorectal Polyp Clinical Trial

Official title:
High-Risk Factors in Patients With Colorectal Polyps a Prospective Case-Control Study

Clinical Trial Summary

This prospective case-control study aimed to analyze and summarize the high-risk factors and susceptible genes of patients with colorectal polyps. According to these high-risk factors, the investigators developed and validated a prediction model for colorectal polyps to identify high-risk individuals, in order to provide clinical basis for the etiology research and the establishment of effective preventive measures.

Clinical Trial Description

A large cohort of eligible participants were included in the analysis, and classified into derivation and validation cohorts at a ratio of 7:3. Demographic and clinicopathological characteristics of participants were utilized to develop a prediction model for colorectal polyps. In the derivation cohort, the LASSO regression method was applied to filter variables and select the most useful high-risk factors. Multivariate logistic regression analysis was used to identify potential predictors and then a prediction model was established. The predictive performance of the model was evaluated with respect to its discrimination, calibration and clinical usefulness. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04684134
Study type Observational [Patient Registry]
Source The First Affiliated Hospital with Nanjing Medical University
Contact
Status Completed
Phase
Start date June 1, 2019
Completion date June 1, 2020
View Details
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