Intraperitoneal Local Anaesthetic in Bowel Surgery

Status Completed

Clinical Trial Summary

This study will evaluate the addition of a local anaesthetic infusion into the abdomen to patient controlled analgesia in the management of postoperative pain and recovery after bowel surgery. Half of the patients will have an infusion of a local anaesthetic called ropivacaine and half will have an infusion of placebo in addition to their normal pain relief.

Clinical Trial Description

The purpose of this randomised controlled blinded trial is to determine the effectiveness in every day practice of intraperitoneal local anaesthetic (IPLA) infusion on postoperative recovery following bowel resection in an optimised Enhanced Recovery After Surgery (ERAS) setting.

The investigators hypothesise that, in an optimised ERAS setting, intraperitoneal instillation and infusion of the local anaesthetic ropivacaine to the site of maximal visceral dissection for 48 hrs will result in an improved functional postoperative recovery following both open and laparoscopic bowel surgery.

This research will provide evidence to allow recommendation on the routine inclusion of IPLA into the multimodal analgesia component of ERAS programs for bowel surgery. ;

Study Design

Related Conditions & MeSH terms

Colorectal Disorders

Clinical Trial Details

NCT number	NCT02449720
Study type	Interventional
Source	Royal Adelaide Hospital
Contact
Status	Completed
Phase	Phase 4
Start date	May 2015
Completion date	December 2016

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05005117` - Laparoscopic Approach for Emergency Colon Resection	N/A
Completed	`NCT04516785` - Reducing Colonoscopies in Patients Without Significant Bowel Disease
Completed	`NCT05994326` - Perioperative Care and Short-term Outcomes of Colorectal Surgery in Addis Abeba
Recruiting	`NCT05432934` - Transversus Abdominis Plane Blocks With and Without Dexamethasone	Phase 1/Phase 2
Recruiting	`NCT03935451` - Postoperative Extended Venous Thromboprophylaxis in Inflammatory Bowel Disease	Early Phase 1
Recruiting	`NCT05726136` - Fluid Challenge and Plasma Volume, During Surgery	Phase 4
Completed	`NCT04849702` - Comparison of the Clavien-Dindo and Comprehensive Complication Index
Not yet recruiting	`NCT06008834` - First-day Discharge Enhanced Recovery After Surgery Protocol for Minimal Invasive Colorectal Surgery	N/A
Completed	`NCT04550156` - Evaluation of the Introduction of a Colorectal Bundle in Left Sided Colorectal Resections	N/A
Completed	`NCT04748744` - Value of Butyrylcholinesterase as a Marker of Surgical Site Infection Following Surgery for Colorectal Diseases
Completed	`NCT02364895` - ColonCancerCheck Mailed Invitations: An Evaluation	N/A
Completed	`NCT05531331` - The Effect of Education on Self-Efficacy and Adaptation to Stoma of Individuals With Stoma	N/A
Recruiting	`NCT04236128` - Home to Stay Mobile App for Colorectal Surgery	N/A
Not yet recruiting	`NCT06356558` - Adapting Enhanced Recovery Programs for Low Health Literacy Patients	N/A
Withdrawn	`NCT01592630` - Effectiveness of Transverse Abdominus Plane Catheter Blocks to Patient-controlled Analgesia in Laparoscopic Colon Resections	Phase 3
Completed	`NCT00868400` - Clinical Value of Preoperative Oral Carbohydrate Loading in Colorectal Surgery	N/A
Completed	`NCT03985111` - Does a Central Venous Line Reduce Perioperative Fluid Administration?
Not yet recruiting	`NCT04704817` - Prospective Database for Colonic or Rectal Resection Surgery Patients
Completed	`NCT02940665` - A Comparison of Protein Intake Between ERAS and Conventional Care After Elective Colorectal Surgery	N/A
Completed	`NCT00667550` - Lower Urinary Tract and Sexual Function in Women Following Surgery for Colorectal Disorders	N/A