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Avelumab Plus Autologous Dendritic Cell Vaccine in Pre-treated Metastatic Colorectal Cancer Patients — AVEVAC  

Colorectal Carcinoma Clinical Trial

Official title:
A Single Arm Phase I-II Multicenter Trial With Avelumab Plus Autologous Dendritic Cell Vaccine to Determine Safety and Preliminary Efficacy of the Combination in Pre-treated Mismatch Repair-proficient (MSS) Metastatic Colorectal Cancer Patients.

Clinical Trial Summary

Single arm Phase I/II multicentric open labeled, with translational sub-study, of avelumab plus autologous dendritic cell vaccine in pre-treated mismatch repair-proficient (MSS) metastatic colorectal cancer patients..

Clinical Trial Description

This 2-phases study will first evaluate two different doses/schema of avelumab plus autologous dendritic cell vaccine (ADC) vaccines, in intention to define which dose is effective without hampering safety. Second phase will consist in an standard analysis of efficacy and progression free survival. It is expected that 4 Spanish Sites will include patients in phase I and 8 Spanish Centers will include patients in the phase II of the study ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03152565
Study type Interventional
Source Grupo Espanol Multidisciplinario del Cancer Digestivo
Contact
Status Completed
Phase Phase 1/Phase 2
Start date March 12, 2018
Completion date October 5, 2020
View Details
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