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Expanded Access to Ulixertinib (BVD-523) in Patients With Advanced MAPK Pathway-Altered Malignancies

Colorectal Cancer Clinical Trial

Official title:
Expanded Access to Ulixertinib (BVD-523) in Patients With Advanced MAPK Pathway-Altered Malignancies

Clinical Trial Summary

The objective of this expanded access program is to provide ulixertinib (BVD-523) for compassionate use in advanced cancer patients with MAPK pathway-altered solid tumor(s), including but not limited to KRAS, NRAS, HRAS, BRAF, MEK, and ERK mutations who have incomplete response to or have exhausted available therapies. Ulixertinib is available for treatment as monotherapy or in combination with other clinically tolerable agent(s), conditionally approved by the drug manufacturer.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

  • Bladder Cancer
  • BRAF Gene Mutation
  • Cholangiocarcinoma
  • Colorectal Cancer
  • ERK Mutation
  • Esophageal Cancer
  • Gastric Cancer
  • Glioblastoma
  • Head and Neck Cancer
  • Hepatocellular Carcinoma
  • HRAS Gene Mutation
  • KRAS Activating Mutation
  • MAPK Gene Mutation
  • MEK Mutation
  • Melanoma
  • Non Small Cell Lung Cancer
  • NRAS Gene Mutation
  • Ovarian Cancer
  • Pancreatic Cancer
  • Small Bowel Cancer
  • Thyroid Cancer
Clinical Trial Details
NCT number NCT04566393
Study type Expanded Access
Source xCures
Contact xCures Clinical Operations
Phone (707) 641-4475
Email expandedaccess@xcures.com
Status Available
Phase
View Details
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