Colorectal Cancer Stage IV Clinical Trial
Official title:
Matrilysin Expression in Different Stages of Colorectal Tumors
Matrix metalloproteinases (MMPs) have been shown to be involved in cancer biology.
Significant expression of MMP-7 (matrilysin) in colorectal cancer is mainly associated with
metastatic disease even though it is expressed in most tumor states. Our purpose is to
analyse MMP-7 in bowel and lymph nodes of different tumor stages and to evaluate its
expression as a potential biomarker of cancer disease in patients surgically treated for
benign and malignant colorectal tumors. Tumoral tissue, lymph nodes and serum samples from
recruited Patients plus serum samples from healthy volunteers are analysed for matrilysin
expression by histology, immunohistochemistry, ELISA and Western blotting.
If Matrilysin increases with increasing dysplasia and cancer disease stage in tumor tissue
as well as in the regional lymph nodes it might be used as a complement in investigating
suspected locally advanced cancer.
n/a
Observational Model: Case Control, Time Perspective: Prospective
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT03594448 -
Detection of MSI in Circulating Tumor DNA of Colorectal Carcinoma Patients
|
||
Completed |
NCT03986541 -
AREG, EREG and EGFR: Response to Anti-EGFR Agents in Colorectal Cancer
|
||
Recruiting |
NCT05354817 -
Impact of FOLFIRINOX Chemotherapy in IV Stage Colorectal Cancer Patients Previously Exposed to Irinotecan, Fluoropyrimidine and Oxaliplatin
|
Phase 2 | |
Recruiting |
NCT05576896 -
Hydroxychloroquine in Combination With Encorafenib and Cetuximab or Panitumumab in the Treatment of Metastatic BRAF-mutated Colorectal Cancer Refractory
|
Phase 2 | |
Completed |
NCT04715061 -
Impact of Aerobic Exercise on Immune Response and Side Effects of Cancer Treatments
|
N/A | |
Terminated |
NCT03149679 -
The p53 Colorectal Cancer Trial
|
Phase 2 | |
Completed |
NCT05550701 -
Prognostic Impact of Increased Lymph Node Yield in Colorectal Cancer Patients With Synchronous Distant Metastasis: a Population-based Study of the US Database and a Chinese Registry
|
||
Enrolling by invitation |
NCT04149613 -
Predictive and Prognostic Value of Inflammatory Markers and microRNA in Stage IV Colorectal Cancer
|
||
Completed |
NCT04425239 -
Intermittent or Continuous Panitumumab Plus FOLFIRI for RAS/B-RAF Wild-type Metastatic Colorectal Cancer
|
Phase 2 | |
Completed |
NCT06329700 -
Parenchymal Sparing Hepatectomy in Post-chemotherapy Liver Atrophy
|
||
Recruiting |
NCT05382741 -
Adjuvant Durvalumab Plus Regorafenib vs Untreated Control in Stage IV Colorectal Cancer Patients With no Evidence of Disease (NED): VIVA Trial
|
Phase 2 | |
Recruiting |
NCT06342440 -
Early Detection of Advanced Adenomas and Colorectal Cancer
|
||
Not yet recruiting |
NCT04917276 -
Treatment Response Prediction System of mCRC Patients Based on CTC
|
||
Not yet recruiting |
NCT06296056 -
Phase I Study of Combined Immune Cell Therapy in Patients With Stage 4 Colorectal Cancer With Metastatic Lesion Who Failed Prior Standard of Care
|
Phase 1 | |
Recruiting |
NCT04714814 -
Mechanisms of Fate Evolution of Colorectal Adenocarcinoma Metastasis
|
||
Not yet recruiting |
NCT05451719 -
Fruquintinib Plus Capecitabine Versus Capecitabine as Maintenance Therapy for Metastatic Colorectal Cancer After First-line Chemotherapy
|
Phase 2 | |
Completed |
NCT03031444 -
Perioperative Chemotherapy Plus Cetuximab Versus Chemotherapy Alone for High Risk Resectable Colorectal Liver Metastasis
|
Phase 2/Phase 3 | |
Completed |
NCT05164419 -
Impact de la Marge de résection Sur la Survie à Long Terme et le Taux de récidive Des Patients Atteints de Cancers Colorectaux opérés au CHUS Entre 2006 et 2016 Pour Des métastases hépatiques
|
||
Recruiting |
NCT05171660 -
Combination With Sintilimab and XELOX+Bevacizumab as 1st Line Therapy in RAS-mutant Metastatic Colorectal Cancer
|
Phase 3 | |
Recruiting |
NCT05426005 -
Cadonilimab for PD-1/PD-L1 Blockade-refractory, MSI-H/dMMR, Advanced Colorectal Cancer
|
Phase 1/Phase 2 |