Colorectal Cancer Metastatic Clinical Trial
Official title:
The Metastatic Colorectal Cancer Patients With Proficient Mismatch Repair (pMMR) / Microsatellite Stable (MSS) or Deficient Mismatch Repair (dMMR) / Microsatellite Instability High (MSI-H) Status Received Palliative Chemotherapy Efficacy and Survival
Deficient mismatch repair (dMMR) or microsatellite instability high (MSI-H) accounts for 4-5% in metastatic colorectal cancer (mCRC). The efficacy and survival of patients with dMMR/MSI-H status received palliative chemotherapy have not clear yet. In this study, the investigators observed the efficacy and survival of dMMR/MSI-H status mCRC patients received palliative first-line chemotherapy.
Colorectal cancer (CRC) is the one of most common cancer in the world. Loss of function of
DNA mismatch repair (MMR) is an important mechanism of CRC development. Mutation or
modification of MMR genes result in MMR protein deficient (dMMR) and microsatellite
instability (MSI). It has been reported that the dMMR or MSI high (MSI-H) phenotype is
present in approximately 15-18% of CRC patients. Most dMMR/MSI-H tumors are sporadic CRC, and
only approximately 3% of dMMR/MSI-H tumors are Lynch syndrome (LS) or hereditary nonpolyposis
colorectal carcinoma (HNPCC).
The dMMR/MSI-H status was reported to be a predictive marker for adjuvant chemotherapy.
Multiple retrospective studies showed that dMMR/MSI-H is correlated with a favorable
prognosis in stage II/III CRC. Previous studies suggested that dMMR/MSI status may be a
predictive marker of decreased benefit form adjuvant monotherapy of 5-fluorouracil (5-FU) in
patients with stage II disease, but not in those with stage III disease. For metastatic
colorectal cancer (mCRC), the relationship of the MMR/MSI phenotype and prognosis is unclear.
Some researchers found that CRC patients with the dMMR/MSI-H phenotype have a worse
prognosis. But other researchers thought the dMMR/MSI-H phenotype is no associate to efficacy
and survival of palliative chemotherapy, even is benefit for efficacy and survival.Therefore,
the aim of this study was to clarify whether the status of dMMR/MSI-H affected
progression-free survival (PFS) in mCRC patients who received first-line palliative
chemotherapy.
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