The p53 Colorectal Cancer Trial

Clinical Trial Summary

Single center, open labeled, phase 2 clinical trial, where patients with metastatic colorectal cancer are selected for treatment with dose dense Cyclophosphamide every second week based on TP53 mutation status; i.e. only patients with TP53 mutated tumors may be included in the treatment arm.

See also
Status	Clinical Trial	Phase
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Terminated	`NCT02316496` - Rechallenge of Cetuximab Combined With Irinotecan as Third-line Chemotherapy in Patients With Metastatic Colorectal Cancer - Phase II Study	Phase 2
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Not yet recruiting	`NCT04525807` - Precision Medicine for Colorectal Cancer Liver Metastasis Guided by Multi-omics Data Under the Umbrella Theory
Completed	`NCT04482608` - The mCRC Patients With pMMR/MSS or dMMR/MSI-H Status Received Palliative Chemotherapy Efficacy and Survival
Recruiting	`NCT03193710` - The Effects of General Anesthetics on Lymphocytes in Patients Undergoing Colorectal Cancer Resection and Mechanism Involved	N/A
Recruiting	`NCT04854213` - PRELUDE-1 (Prospective Evaluation of Radiotherapy-induced Biologic Effects in Colorectal Cancer Oligometastatic Patients With LUng-limited Disease: Evolution of Cancer Genetics and Regulatory Immune Cells)	N/A
Suspended	`NCT04108481` - Immunotherapy With Y90-RadioEmbolization for Metastatic Colorectal Cancer	Phase 1/Phase 2
Completed	`NCT03144804` - A Phase 2 Study of Lamivudine in Patients With p53 Mutant Metastatic Colorectal Cancer	Phase 2
Completed	`NCT03142516` - FOLFIRI + Panitumumab First-line Treatment in Elderly Patients With Unresectable Metastatic Colorectal Cancer, RAS/BRAF Wild-type and Good Performance Status	Phase 2
Active, not recruiting	`NCT01910610` - Multi-Line Therapy Trial in Unresectable Metastatic Colorectal Cancer	Phase 3
Recruiting	`NCT05759728` - A Study of CNA3103 (LGR5-targeted, Autologous CAR-T Cells) Administered to Subjects With Metastatic Colorectal Cancer	Phase 1/Phase 2

NCT number	NCT03149679
Study type	Interventional
Source	Haukeland University Hospital
Contact
Status	Terminated
Phase	Phase 2
Start date	May 9, 2017
Completion date	August 7, 2020

The p53 Colorectal Cancer Trial

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms