Colorectal Cancer Metastatic Clinical Trial
— earlyPETmCRCOfficial title:
Evaluation of Prognostic and Predictive Value of PETSCAn in ColoRectal Cancer (CRC)
Study hypothesis : early decrease in fdg-pet measured SUV max after 1 cycle of chemotherapy
can accurately predict response of chemotherapy as assessed by conventional radiology after
3 cycles of chemotherapy.
FDG-PET imaging will be done at J0 and J14 of a new line of chemotherapy treatment in
metastatic colorectal cancer.
SUV max will be recorded and delta SUVmax will be compared to the results of conventional
radiological evaluation after 3 courses of chemotherapy. Results will also be compared to
the time to disease progression.
Status | Completed |
Enrollment | 40 |
Est. completion date | July 2010 |
Est. primary completion date | July 2010 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - advanced colorectal cancer - evaluable disease - signed informed consent Exclusion Criteria: - no other cancer - no other life-threatening condition - unwillingness or inability to sign informed consent - active cerebral metastasis |
Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Belgium | Institut Jules Bordet, Université Libre de Bruxelles | Brussels |
Lead Sponsor | Collaborator |
---|---|
Jules Bordet Institute |
Belgium,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | compare fdg-pet variations after 1 course of chemotherapy to chemotherapy outcome measured by time to disease progression | Time to Disease progression | No | |
Secondary | compare fdg-pet variations after 1 course of chemotherapy to chemotherapy outcome measured by tumour response rate following RECIST criteria. | response rate | No |
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