Transcriptomic Study of IBD-associated Colorectal Cancer

Colorectal Cancer, Genetics of Clinical Trial

Official title:

Transcriptiomic Analysis of Inflammatory Bowel Disease-associated Colorectal Cancer. A French Retrospective Study of 26 Cases Identified at the Nancy University Hospital

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05060770
• Other study ID #: 2021PI125
• Status: Completed
• Start date: January 1, 2010
• Est. completion date: January 1, 2021

Study information

• Verified date: September 2021
• Source: Central Hospital, Nancy, France
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

Chronic inflammatory bowel disease (IBD) is associated with an increased risk of colorectal cancer (CRC) in historical cohorts. The pathways of oncogenesis of these CRCs, which are very different clinically from de novo CRCs, are currently unknown. The aim of our work is to identify specific molecular signatures of CRC occurring in the setting of IBD.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 26
• Est. completion date: January 1, 2021
• Est. primary completion date: January 1, 2021
• Gender: All
• Age group: 18 Years to 100 Years

Eligibility

Inclusion Criteria:

• Person 18 years of age or older

• Person with colorectal cancer in the context of IBD

• Person who has received complete information on the organization of the research and who has signed an informed consent

• Person affiliated to a social security plan or beneficiary of such a plan.

Exclusion Criteria:

• Person referred to in articles L. 1121-5, L. 1121-7 and L1121-8 of the public health code:

• Pregnant woman, parturient or nursing mother

• Minor (not emancipated)

• Adult person subject to a legal protection measure (guardianship, curatorship, safeguard of justice)

• Person of legal age who is unable to express his or her consent

• Person deprived of liberty by a judicial or administrative decision, persons subject to psychiatric care under articles L. 3212-1 and L. 3213-1.

Related Conditions & MeSH terms

• Colorectal Cancer, Genetics of
• Colorectal Neoplasms
• Inflammatory Bowel Diseases

Intervention

Genetic:
• transcriptomic analysis
transcriptomic analysis on preserved tumor tissue

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Central Hospital, Nancy, France

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	IBD associated CRC oncogenesis	Percentage of gene expression variation in CRC tumor tissue samples in the following groups patients with CRC and IBD	1 year