Colonic Neoplasms Clinical Trial
Official title:
Endo-cuff Assisted Colonoscopy Versus Standard Colonoscopy for Polyp Detection in Bowel Cancer Screening Patients: A Randomised Controlled Trial. The E-CAP Study
The study evaluates whether the use of a novel endoscopic cap (the endo-cuff) at the tip of a colonoscope improves the numbers of polyps detected during bowel cancer screening colonoscopy. Half the patients will have standard colonoscopy and half will have colonoscopy with the cap attached.
Problem statement:
In England, everyone in the age group of 60-69 years is invited to participate in bowel
cancer screening. Those who test positive in the initial screening stool test are invited to
have a colonoscopy. The purpose of colonoscopy is to detect any obvious cancers, and in the
absence of obvious cancers the purpose is to detect and remove all the polyps present in the
colon, as polyps have the potential to develop into cancers. However, colonoscopy still
misses up to 25% of polyps. Cap assisted colonoscopy improves polyp detection but still
misses a significant number of polyps. There is a need for an improved cap design which will
help improve polyp detection.
Research question/hypothesis:
Does using an endocuff on a colonoscope improve polyp detection as compared to standard
colonoscopy in bowel cancer screening patients?
Study design:
Parallel group, single blinded randomised controlled trial
Study participants:
Patients attending for colonoscopy under the bowel cancer screening programme
Planned sample size: 534
Planned study period: 12 months
Primary objective:
To assess the impact of endocuff assisted colonoscopy on the number of polyps detected per
patient
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Screening
Status | Clinical Trial | Phase | |
---|---|---|---|
Terminated |
NCT03746353 -
Early Closure Versus Conventional Closure in Postoperative Patients With Low Anteriresection for Rectal Cancer
|
N/A | |
Recruiting |
NCT05809999 -
IBD Neoplasia Surveillance RCT
|
N/A | |
Recruiting |
NCT06041945 -
Artificial Intelligence to Implement Cost-saving Strategies for Colonoscopy Screening Based on in Vivo Prediction of Polyp Histology
|
N/A | |
Not yet recruiting |
NCT02688699 -
Additive Hemostatic Efficacy of EndoClot After EMR or ESD in the Gastrointestinal Tract
|
Phase 4 | |
Not yet recruiting |
NCT03175146 -
A Study to See Whether Stereotactic Body RadioTherapy (SBRT) Can Shrink Tumours Within the Liver Safely
|
N/A | |
Not yet recruiting |
NCT01929499 -
Efficacy of Adjuvant Cytokine-induced Killer Cells in Colon Cancer
|
Phase 2 | |
Completed |
NCT01681472 -
PK/PD Investigation of Modufolin (Arfolitixorin) in Plasma, Tumor and Adjacent Mucosa Adjacent Mucosa in Patients With Colon Cancer
|
Phase 1/Phase 2 | |
Completed |
NCT01438645 -
ScopeGuide-assisted Colonoscopy Versus Conventional Colonoscopy
|
N/A | |
Completed |
NCT00535652 -
Concentration of Ertapenem in Colorectal Tissue
|
Phase 4 | |
Terminated |
NCT00267787 -
Molecular Genetic and Pathological Studies of Anal Tumors
|
||
Completed |
NCT05498051 -
Fluorescent Sentinel Lymph Node Identification in Colon Carcinoma Using Submucosal Bevacizumab-800CW.
|
N/A | |
Recruiting |
NCT05068180 -
Low-dose Neuroleptanalgesia for Postoperative Delirium in Elderly Patients
|
Phase 4 | |
Recruiting |
NCT03314896 -
Laparoscopic Surgery for T4 Tumor of the Colon Cancer (LST4C Trial)
|
N/A | |
Not yet recruiting |
NCT02852915 -
Laparoscopic Surgery for T4 Tumor of the Colon Cancer
|
Phase 3 | |
Not yet recruiting |
NCT02777437 -
Laparoscopic Surgery VS Laparoscopic Surgery + Neoadjuvant Chemotherapy for T4 Tumor of the Colon Cancer
|
Phase 2/Phase 3 | |
Completed |
NCT00997802 -
Japanese National Computed Tomographic (CT) Colonography Trial
|
N/A | |
Completed |
NCT01056913 -
NITI CAR27 (ColonRing) Compression Anastomosis in Colorectal Surgery
|
Phase 4 | |
Completed |
NCT00470782 -
Aerobic Capacity and Body Composition in Colon Cancer Patients
|
N/A | |
Completed |
NCT00537901 -
First-Line Bevacizumab and Chemotherapy in Metastatic Cancer of the Colon or Rectum - International Study
|
N/A | |
Completed |
NCT00275210 -
MOSAIC - Multicenter International Study of Oxaliplatin/ 5FU-LV in the Adjuvant Treatment of Colon Cancer
|
Phase 3 |