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Clinical Trial Details — Status: Not yet recruiting

Administrative data

NCT number NCT02824835
Other study ID # IDO123
Secondary ID
Status Not yet recruiting
Phase N/A
First received June 27, 2016
Last updated July 2, 2016
Start date July 2016
Est. completion date December 2017

Study information

Verified date July 2016
Source Meir Medical Center
Contact Ido Laish, MD
Phone + 972-9-7473261
Email ido.lish@clalit.org.il
Is FDA regulated No
Health authority Israel: Ministry of Health
Study type Observational

Clinical Trial Summary

The purpose of this study is to determine the effects of the plant hormones strigolactones, on cell cultures of colonic polyps and colorectal cancer.


Description:

Strigolactones have been shown to anti-proliferative and pro-apoptotic effects in cell cultures of breast and prostate origin, partially by down-regulation of cyclin B1 and induction of cell cycle arrest. In this study the investigators intend to take biopsies from benign colonic polyps and cancer tissue, culture intestinal explants and generate immortalized primary cells as a platform to assess the effect of this plant hormone on cell viability, cell mobility, apoptosis and cytoskeleton modifications.


Recruitment information / eligibility

Status Not yet recruiting
Enrollment 150
Est. completion date December 2017
Est. primary completion date December 2017
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 18 Years and older
Eligibility Inclusion Criteria:

- Patients with positive findings during colonoscopy

Exclusion Criteria:

- Patients below 18 years old

- Patients who cannot sign a consent form

Study Design

Observational Model: Case-Only, Time Perspective: Prospective


Related Conditions & MeSH terms


Intervention

Procedure:
biopsy during colonoscopy
sampling the lesion with forcept biopter

Locations

Country Name City State
n/a

Sponsors (1)

Lead Sponsor Collaborator
Meir Medical Center

References & Publications (2)

Mayzlish-Gati E, Laufer D, Grivas CF, Shaknof J, Sananes A, Bier A, Ben-Harosh S, Belausov E, Johnson MD, Artuso E, Levi O, Genin O, Prandi C, Khalaila I, Pines M, Yarden RI, Kapulnik Y, Koltai H. Strigolactone analogs act as new anti-cancer agents in inhibition of breast cancer in xenograft model. Cancer Biol Ther. 2015;16(11):1682-8. doi: 10.1080/15384047.2015.1070982. Epub 2015 Jul 20. — View Citation

Pollock CB, Koltai H, Kapulnik Y, Prandi C, Yarden RI. Strigolactones: a novel class of phytohormones that inhibit the growth and survival of breast cancer cells and breast cancer stem-like enriched mammosphere cells. Breast Cancer Res Treat. 2012 Aug;134(3):1041-55. doi: 10.1007/s10549-012-1992-x. Epub 2012 Mar 29. — View Citation

Outcome

Type Measure Description Time frame Safety issue
Primary percentage of cells with reduced viability after dose-dependent exposure 24 hours of exposure to strigolactone No
Primary percentage of cells in G2/M arrest after dose-dependent exposure analysis of cell cycle 24 hours of exposure to strigolactone No
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