The Study of Adenoma Characteristics of the COX-2 & DNMT Expressions in

Status Completed

Clinical Trial Summary

The colorectal cancer is the first incidence and ranks the third cancer-death cause in Taiwan. Based on the Taiwan-national colon cancer screening program, early colorectal cancer detection rate and the survival are markedly improved. Besides to disclose the early cancer, there are vast populations to be disclosed with colon adenoma. Some of colon adenoma really presents as advanced colon adenoma (ACA) to carry higher risk of recurrence and even cancer progression. The current clinical guidelines raise strategy for colonoscopy surveillance based on the results of the index colonoscopy to categorize the patients into different risks of colon polyp recurrence and early detection of colorectal cancer. It is worthy to validate whether the real scenario of Taiwan colonoscopy surveillance can fulfill the guidelines worldwide. Furthermore, it shall be of clinical importance to elucidate out the high risky group who may be commonly disclosed during intense colonoscopy surveillance and to disclose with advanced adenoma. Accordingly, the domestic amending to the worldwide guideline shall be in need and need a more reliable biomarker to predict the recurrence of colon adenoma during surveillance colonoscopy. Concerning, cyclooxygenase-2 (COX-2) and DNA methyltransferases (DNMT) are involved during colorectal carcinogenesis via chronic inflammatory process and early tumorigenesis. This study proposes COX-2 and DNMT shall be potential biomarkers correlating to the recurrence of colon adenoma disclosed during surveillance colonoscopy in Taiwan. We thus conduct a prospective study, containing at least 1,400 cases, who will undergo surveillance colonoscopy in National Cheng Kung University Hospital in the next year. The study shall be a large-case study to answer whether the surveillance interval of the surveillance colonoscopy can be fulfilled to the suggestion of the 2012 United States Multi-society Task Force (USMTF) on colorectal cancer guideline. Factors that affect the detection of polyps in the surveillance will be explored. Based on the invitation of the patients to receive surveillance colonoscopy, the study also test whether COX-2 or DNMT over-expression are markers to predict polyps recurrence and to identify the risky patient deserve for earlier colonoscopy.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05568810
Study type	Observational
Source	National Cheng-Kung University Hospital
Contact
Status	Completed
Phase
Start date	August 1, 2014
Completion date	July 31, 2016

View Details

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT05551052` - CRC Detection Reliable Assessment With Blood
Terminated	`NCT04555135` - A Clinical Study To Measure The Effect Of Use Of Artificial Intelligence (AI) Enabled Computer Aided Detection (CADe) Assistance Software In Detecting Colon Polyps During Standard Colonoscopy Procedures	N/A
Completed	`NCT03390907` - Hybrid APC Assisted EMR for Large Colon Polyps	N/A
Completed	`NCT03551379` - A Double Balloon Endoscopic Platform for ESD
Recruiting	`NCT05405530` - Nasal Mask Kit in Gastrointestinal Endoscopy	N/A
Completed	`NCT05030870` - Capnographic Monitoring in Gastrointestinal Endoscopy for Elderly Patients	N/A
Completed	`NCT03742232` - Study Comparing the Bowel Cleansing Efficacy of PLENVU® Versus SELG-ESSE® Using a 2-Day Split Dosing Regimen.	Phase 4
Completed	`NCT03444090` - Impacts of Inspection During Instrument Insertion on Colonoscopy Quality	N/A
Enrolling by invitation	`NCT03700593` - Feasibility and Safety of Single Port Robot in Colorectal Procedures
Recruiting	`NCT04063280` - Prospective Randomized Controlled Trial Describing the Recurrence Rate of Adenomas in Sessile or Flat Colonic Lesions 15mm or Larger Receiving Post-resection Site Treatment With Snare Tip Soft Coagulation	N/A
Completed	`NCT04378088` - The Colon Endoscopic Bubble Scale (CEBuS); Validation Study
Completed	`NCT03891290` - Collecting Recorded Videos of Colonoscopy Screening Tests
Terminated	`NCT04628052` - The Effect of Music on Colonoscopy (MUSICOL)	N/A
Terminated	`NCT05579444` - Systems Biology of Gastrointestinal and Related Diseases
Not yet recruiting	`NCT06073561` - Underwater Endoscopic Mucosal Resection	N/A
Not yet recruiting	`NCT06317727` - PULSed Field ablAtion of coloRectal Polyps
Active, not recruiting	`NCT04369053` - Prevention of Colorectal Cancer Through Multiomics Blood Testing
Completed	`NCT03329339` - The Effect of 1L Polyethylene Glycol Plus Ascorbic Acid With Prepackaged Low-Residue Diet for Bowel Preparation	N/A
Completed	`NCT03943758` - a Low-residue Diet for Bowel Preparation	N/A
Not yet recruiting	`NCT04837690` - UEMR for Medium-sized Pedunculated Colon Polyps

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

The Study of Adenoma Characteristics of the COX-2 and DNMT Expressions in the Index Colonoscopy to Predict the Polyp Recurrence During Surveillance

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms