Colon, Irritable Clinical Trial
Official title:
The Role of Serine-Proteases in Gastrointestinal Function and Irritable Bowel Syndrome
The proposed pilot project for this seed grant focuses on the role of intestinal
serine-proteases in the pathogenesis of diarrhea-predominant IBS (D-IBS). In this study we
will further assess serine-protease activity in patients with D-IBS and also explore a
possible mechanism by which these proteases can lead to alterations in intestinal physiology
and symptoms in these patients.
The general hypotheses for the proposed research are that (A) the levels of fecal
serine-protease in patients with D-IBS are abnormally increased (B) this abnormal
serine-protease activity leads to/is associated with an abnormal increase in intestinal
permeability and therefore enables (C) chronic stimulation and activation of the mucosal
immune system in these patients. In addition, it is aim to determine whither periodontal
inflammation is associated with intestinal permeability and serine protease activity.
n/a
Observational Model: Case Control, Time Perspective: Prospective
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