Observing the Perioperative Effects of Prehabilitation in Colorectal Cancer Patients

Colon Cancer Clinical Trial

Official title:

Observing the Perioperative Effects of Prehabilitation in Colorectal Cancer

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04762914
• Other study ID #: 2021.038N
• Status: Completed
• Start date: September 1, 2018
• Est. completion date: December 31, 2019

Study information

• Verified date: February 2021
• Source: Medway Primary Care Trust
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Quality Improvement Project to evaluate how prehabilitation can be incorporated into our colorectal cancer pathway and assess its clinical benefits.

Description:

The aim was to evaluate how prehabilitation (PH) can be incorporated into our colorectal cancer pathway and assess its clinical benefits.

Patients underwent PH (exercise, nutrition and psychological support) before resection of colorectal carcinoma in a DGH over fourteen months. Patients were matched by operation, age, sex and ASA to non-prehabilitation (NPH) patients using a prospectively maintained database. Length of stay (LoS) and complication rate and 90-day readmission rates were compared using Wilcoxon and McNemar's methods.

Prehabilitation significantly improved peak VO2 and AT. This corresponds to a reduction in predicted 30-day mortality. Despite a higher Charlson index LoS was unchanged suggesting prehabilitation may permit safe resection in comorbid patients.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 52
• Est. completion date: December 31, 2019
• Est. primary completion date: December 31, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Adults over the age of 18 who had prehabilitation for colorectal cancer

Exclusion Criteria:

• Children

• Patients who had prehabilitation but not for colorectal cancer

Related Conditions & MeSH terms

• Colon Cancer
• Colorectal Neoplasms

Intervention

Other:
• Prehabilitation
Prehabilitation is a multimodal and multidisciplinary person-centred perioperative approach involving supervised exercise training, nutritional education, management of polypharmacy and psychological advice.

Locations

Country	Name	City	State
United Kingdom	Medway Hospitals NHS Trust	Gillingham	Kent

Sponsors (1)

Lead Sponsor	Collaborator
Medway Primary Care Trust

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Length of stay	Time spent in hospital	From date of operation to date of discharge in number of days over a 90 day follow up period
Primary	Complication rate	All Clavien-Dindo complications	Follow up over a period of 90 days following operation
Secondary	Anaerobic threshold	Measured by looking at CPET results pre- and post- prehab	CPET performed before prehabilitation and after prehabilitation (median of 36 days)