Colon Cancer Clinical Trial
Official title:
MoTriColor: A Phase II Study of Vinorelbine in Advanced BRAF-like Colon Cancer
Vecchione et al showed that suppression of RANBP2 results in mitotic defects only in
BRAF-like colon cancer (CC) cells, which leads to cell death. Mechanistically, RANBP2
silencing reduces microtubule outgrowth from the kinetochores, thereby inducing spindle
perturbations, providing an explanation for the observed mitotic defects. Vinorelbine mimics
RANPB2 silencing in BRAF-like and BRAFV600E CC cell lines.
These preclinical data represent a strong rationale to also explore the anti-tumor activity
of vinorelbine in patients with advanced BRAF-like (both BRAFm and BRAF wild type) CC. Tumors
having this gene signature are referred to as "BRAF-like" and have a similar poor prognosis
irrespective of the presence of BRAF(V600E) mutation. Since vinorelbine is standard of care
in advanced breast and NSCLC, there is ample experience with the dose and schedule as well as
with the safety profile and supportive measures required to prevent side-effects.
n/a
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