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NCT03014284 Clinical Trial

Novel Listeria Vectors Secreting Gut Flora-Altering Agents to Prevent Colon Cancer and Treat Colitis

Colon Cancer Clinical Trial

Official title:
Novel Listeria Vectors Secreting Gut Flora-Altering Agents to Prevent Colon Cancer and Treat Colitis

Clinical Trial Details — Status: Withdrawn

Administrative data
NCT number NCT03014284
Other study ID # CTMS 16-0101
Secondary ID HSC20160555H
Status Withdrawn
Phase
First received
Last updated
Start date January 20, 2017
Est. completion date September 12, 2018

Study information
Verified date February 2018
Source The University of Texas Health Science Center at San Antonio
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

This is a simple tissue collection study with no therapeutic intent. Colon tissues will be taken from standard of care procedures. Tissues will be tested for their functions, expression of immune co-signaling molecules and reactions to transduction with recombinant Listeria vectors to assess effects on expression of B7-H1 and cytokines.

Recruitment information / eligibility
Status Withdrawn
Enrollment 0
Est. completion date September 12, 2018
Est. primary completion date September 12, 2018
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 100 Years
Eligibility Inclusion Criteria:

- Able to provide informed consent (or have consent provided through a guardian)

- No immune-modulating drug use during study or within 30 days prior to enrollment

- Having colon material collected as part of standard of care

Exclusion Criteria:

- Unable to provide informed consent (or have consent provided through a guardian)

- Not having colon material collected as part of standard of care

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
United States Cancer Therapy & Research Center at UTHSCSA San Antonio Texas

Sponsors (1)
Lead Sponsor Collaborator
The University of Texas Health Science Center at San Antonio

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Expression of B7-H1 To assess the ability of recombinant Listeria to modulate B7-H1 in human colonic tissues Baseline tissue collection
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