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NCT02567942 Clinical Trial

Assessment of the Anesthetic Effect on the Activity of Immune Cell in Patient With Colon Cancer

Colon Cancer Clinical Trial

Official title:
Assessment of the Anesthetic Effect on the Activity of Immune Cell in Patient With Colon Cancer

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT02567942
Other study ID # KUH1160089
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date February 2016
Est. completion date April 2018

Study information
Verified date April 2021
Source Konkuk University Medical Center
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Anesthetics agents has variety inflammation during the cancer surgery. This perioperative inflammation can influence to cancer metastasis or recurrence. The purpose of this study is to prove the variation of immune cell activity between preoperative and postoperative period.

Description:

The patients were allocated randomly to receive propofol or sevoflurane. Also, a total of 18ml of blood sample was obtained for total 3 times in consecutive order. 1. immediate before anesthesia induction 2. postoperative 1 hours 3. postoperative 24 hours Serum in blood will be obtained and activity of helper T cell, natural killer cell and level of serum cytokine will be evaluated by flow cytometry or enzyme-linked immunosorbent assay

Recruitment information / eligibility
Status Completed
Enrollment 153
Est. completion date April 2018
Est. primary completion date April 2018
Accepts healthy volunteers No
Gender All
Age group 20 Years and older
Eligibility Inclusion Criteria: - patient who was planned to undergo colon cancer surgery. Exclusion Criteria: - age < 20 years old - history of hypersensitivity reaction in propofol or sevoflurane - history of previous cancer - patient with ongoing inflammation

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• propofol group
Patient will be anesthetized by using propofol infusion during operation
• sevoflurane group
Patient will be anesthetized by using sevoflurane inhalation during operation

Locations
Country Name City State
Korea, Republic of Konkuk University Medical Center Seoul

Sponsors (1)
Lead Sponsor Collaborator
Konkuk University Medical Center

Country where clinical trial is conducted

Korea, Republic of, 

Outcome
Type Measure Description Time frame Safety issue
Other change of percentage of CD39 and CD73 change of percentage of CD39 and CD73 (scores range from 0 to 100) preoperative time. postoperative 1 hours and 24 hours
Primary natural killer cell activity change of percentage of natural killer cell (scores range from 0 to 100) preoperative time. postoperative 1 hours and 24 hours
Secondary helper T cell activity change of percentage of helper T cell (scores range from 0 to 100) preoperative time. postoperative 1 hours and 24 hours
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