Measurements of Colloid Osmotic Pressure in Interstitial Fluid and Plasma

Colloid Osmotic Pressure Clinical Trial

Official title:

Measurements of Colloid Osmotic Pressure in Interstitial Fluid and Plasma, a Methodological Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01044979
• Other study ID #: 071223
• Status: Completed
• Phase: N/A
• First received: December 17, 2009
• Last updated: July 3, 2014
• Start date: December 2009
• Est. completion date: September 2010

Study information

• Verified date: July 2014
• Source: Haukeland University Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: Norway:National Committee for Medical and Health Research Ethics
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to evaluate a method of sampling interstitial fluid from subcutaneous sewn wicks.

Description:

Fluid loss from circulating plasma volume is one of the contributors of oedema formation. Measurement of colloid osmotic pressure (COP) both in plasma and in interstitial fluid can be utilised in planing of fluid therapy in patients with oedema. Different methods of sampling interstitial fluid are well validated in animal models, but not in human. Sampling of interstitial fluid by subcutaneous sewn wicks is a well-known method and can be painful. Local anaesthetics can reduce pain. By comparing interstitial fluid taken from areas with or without application of local anaesthetics, a possible influence in COP values can be detected.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 50
• Est. completion date: September 2010
• Est. primary completion date: September 2010
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Adults over 18 years

Exclusion Criteria:

• Ongoing illness

• Medication

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Colloid Osmotic Pressure

Locations

Country	Name	City	State
Norway	Haukeland University Hospital	Bergen

Sponsors (1)

Lead Sponsor	Collaborator
Haukeland University Hospital

Country where clinical trial is conducted

Norway, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Colloid osmotic pressure		60 and 90 minuttes after implanting wicks	No