Colitis, Ulcerative Clinical Trial
Official title:
Low-dose Azathioprine and Allopurinol- Versus Azathioprine Monotherapy in Patients With Ulcerative Colitis: An Investigator-initiated, Open, Multicentre, Parallel-arm, Randomised Controlled Trial
Azathioprine is considered first line immunomodulatory therapy for patients with ulcerative
colitis. Up to 50% are treatment failures or experience adverse events leading to treatment
withdrawal. Recent evidence suggests that the combination of allopurinol and low dose
azathioprine increases the proportion of treatment responders and reduce the risk of adverse
events.
Objectives: To evaluate the beneficial and harmful effects of low dose azathioprine and
allopurinol versus standard azathioprine monotherapy in patients with ulcerative colitis.
Investigator initiated, multicentre, parallel arm, open, randomised controlled trial with blinded assessment ;
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